Abstract Objective To explore the clinical effect of Gliclazide combined with Acarbose in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 100 cases of T2DM patients admitted to the People′s Hospital of Yangdong District in Yangjiang City from June 2019 to July 2020 were selected as the research objects.According to random number table method,they were divided into the control group and the observation group,with 50 cases in each group.The control group was given Acarbose treatment,while the observation group was given Gliclazide on the basis of the control group.The course of treatment was 12 weeks.The levels of fasting blood glucose(FPG),2 h postprandibular blood glucose(2 h PG),glycosylated hemoglobin(HbA1c),serum hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and the incidence of adverse reactions during treatment were compared between the two groups before and after treatment.Results There were no statistically significant differences in the levels of FPG,2 h PG and HbA1c between the two groups before treatment(P＞0.05).After treatment,the levels of FPG,2 h PG and HbA1c in the two groups were lower than those before treatment,and the levels of FPG,2 h PG and HbA1c in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).There were no statistically significant differences in the levels of hs-CRP,IL-6 and TNF-α between the two groups before treatment(P＞0.05).After treatment,the levels of hs-CRP,IL-6 and TNF-α of the two groups were lower than those before treatment,and the levels of hs-CRP,IL-6 and TNF-α of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Gliclazide combining with Acarbose in the treatment of T2DM can effectively reducing the levels of FPG,2 h PG,HbA1c,hs-CRP,IL-6 and TNF-α,without increasing the adverse reactions.
TAN Qiu-ling,LUO Xiao-jing,CHEN Qiao-rong. Clinical effect of Gliclazide combined with Acarbose in the treatment of type 2 diabetes mellitus[J]. 中国当代医药, 2021, 28(17): 64-66转70.
