摘要目的 探讨阿替普酶联合丁苯酞早期治疗急性缺血性脑卒中的效果及对纤维蛋白原水平的影响。方法 将2018年10月—2020年10月广东省江门市人民医院收治的136 例急性缺血性脑卒中患者按照随机数字表法分为阿替普酶组（68 例，采用阿替普酶静脉溶栓治疗）和联合组（68 例，在阿替普酶静脉溶栓治疗的基础上给予静脉滴注丁苯酞氯化钠注射液）。比较两组溶栓前和溶栓后24 h 神经功能缺损评分，溶栓前和溶栓后1、4 h 纤维蛋白原水平及疗效。结果 溶栓后24 h 两组患者的神经功能缺损评分均低于溶栓前，且联合组患者的神经功能缺损评分低于阿替普酶组，差异有统计学意义（P＜0.05）。联合组患者的治疗总有效率高于阿替普酶组，差异有统计学意义（P＜0.05）。溶栓后1、4 h 两组患者的纤维蛋白原水平低于溶栓前，差异有统计学意义（P＜0.05）；且联合组患者的纤维蛋白原水平低于阿替普酶组，差异有统计学意义（P＜0.05）。结论 阿替普酶联合丁苯酞早期治疗急性缺血性脑卒中效果显著，有利于患者神经功能的改善并能降低纤维蛋白原水平。
Abstract：Objective To investigate the effect of Alteplase combined with Butylphthalide in the early treatment of acute ischemic stroke and its influence on the level of fibrinogen. Methods From October 2018 to October 2020, 136 patients with acute ischemic stroke in People′s Hospital of Jiangmen, Guangdong Province were divided into the Alteplase group (68 cases, intravenous thrombolytic therapy with Alteplase) and the combination group (68 cases, intravenous infusion of Butylphthalide Sodium Chloride Injection on the basis of Alteplase intravenous thrombolytic therapy)according to the random number table method. The neurological deficit score before and 24 hours after thrombolysis,the levels of fibrinogen before and 1 and 4 hours after thrombolysis and curative effect were compared between the two groups. Results At 24 hours after thrombolysis, the neurological deficit scores of the two groups were lower than those before thrombolysis, and the neurological deficit score of the combination group was lower than that of the Alteplase group, the differences were statistically significant (P＜0.05). The total effective rate of treatment in the combination group was higher than that in the Alteplase group, and the difference was statistically significant (P＜0.05). The fibrinogen levels of the two groups at 1 and 4 h after thrombolysis were lower than those before thrombolysis, the differences were statistically significant (P＜0.05), and the fibrinogen levels of the combined group were lower than those of the Alteplase group, the differences were statistically significant (P＜0.05). Conclusion Alteplase combined with Butylphthalide has a significant effect in the early treatment of acute ischemic stroke, which is conducive to the improvement of neurological function and can reduce the level of fibrinogen.
万婷玉；王丹. 阿替普酶联合丁苯酞早期治疗急性缺血性脑卒中的效果及对纤维蛋白原水平的影响[J]. 中国当代医药, 2021, 28(19): 120-122转126.
WAN Ting-yu WANG Dan. Effect of Alteplase combined with Butylphthalide in the early treatment of acute ischemic stroke and its influence on the level of fibrinogen. 中国当代医药, 2021, 28(19): 120-122转126.
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