Abstract：ObjectiveTo observe the effect of Hp eradication of Compound Bismuth and Magnesium Granules quadruple therapy on chronic gastritis and peptic ulcer.Methods150 patients with Hp infection treated in People′s Hospital of Xishuangbanna Prefecture from January 2012 to December 2015 were selected and they were divided into 3 groups,and there were 50 cases in each group.The standard triple group was given Rabeprazole,Amoxicillin,Clarithromycin for 14 days.Compound Bismuth and Magnesium Granules quadruple group was added Compound Bismuth and Magnesium Granules,while Bismuth Potassium Citrate quadruple group was added Bismuth Potassium Citrate for oral administration for 14 days on the basis of the standard triple treatment respectively.Hp eradication,remission of symptoms and adverse reaction of the three groups were observed.ResultsHp eradication rate and symptoms remission rate of abdominal pain and abdominal distension and acid belching of Compound Bismuth and Magnesium Granules quadruple group were higher than those of standard triple group,and there were notable statistical differences(P＜0.01).Hp eradication rate of Compound Bismuth and Magnesium Granules quadruple group was also higer than that of Bismuth Potassium Citrate quadruple group,and there was a statistical difference(P＜0.05).There was a statistical difference of symptoms remission rate of abdominal pain and distension of Bismuth Potassium Citrate quadruple group and standard triple group(P＜0.05).The adverse reaction among three groups had no statistical significance (P＞0.05).ConclusionCompound Bismuth and Magnesium Granules quadruple therapy in the clinical treatment on Hp－eradication and symptoms remission has a better effect than the other groups.What′s more,it does not add adverse reaction,and it has a certain advantage and a better safety in the treatment of Hp eradication.
Dooley CP，Cohen H，Fitzgibbons PL，et al.Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons[J].N Engl J Med，1989，321（23）：1562-1566.
[3]
Warren JR.Helicobacter：the ease and difficulty of a new discovery （Nobel lecture）[J].Chem Med Chem，2006，1（7）：672-685.
[4]
WeiZ，YingL，WenG，etal.RomeⅢcriteria cannot distinguish patients with chronic gastritis from those functional dyspepsia patients[J].Helicobacter，2014，19（2）：124-128.
[5]
Graham DY.Helicobacter pylori update：gastric cancer，reliable therapy，and possible benefits[J].Gastroenterology， 2015，148（4）：719-731.e3.
O′Mahony R，Al-Khtheeri H，Weerasekera D，et al.Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori[J].World J Gastroenterol，2005，11（47）：7499-7507.
[11]
Li Q，Wang NN，Hu FL，et al.Study of compound bismuth and magnesium granules on clearance of helicobacter pylori infectioninKMmice[J].IntJClinExpMed，2016，9（7）：12 888-12 895.
京公网安备 11010502046607号