ObjectiveTo investigate the effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis laparoscopic surgery.MethodsA total of 71 cases female patients with ovarian endometriosis,fertility intention and received conservative operation who treated in our hospital from June 2012 to June 2016 were retrospectively analyzed.According to the medication they received,patients were divided into three groups,including group NON(no medication,n＝26),group LEU(Leuprorelin,3.75 mg/28d,n＝24),and group GOS(Goserelin,3.6 mg/28d,n＝21).The clinical efficacy,recurrence rates after treatment,rates of successful pregnancy,alleviated rates of dysmenorrhea and incidence of adverse reaction of each group were compared.ResultsThe clinical efficiency of group NON (61.5%)was significantly lower than group LEU(70.8%)and group GOS(76.2%),and the differences were statistically significant(P＜0.05).The clinical efficiency of group LEU were compared with group GOS,and the difference was not statistically significant(P＞0.05).The successful pregnancy rate(38.5%),dysmenorrhea alleviated rate(65.3%)of group NON were significantly lower than that of group LEU(70.8%,75.0%)and group GOS(76.2%,76.2%),the differences were statistically significant(P＜0.05).The recurrence rates of group NON(46.2%)was significantly higher than group LEU(25.0%)and group GOS(28.6%),the differences were statistically significant(P＜0.05).The recurrence rate,successful pregnancy rate,dysmenorrhea alleviated rate and incidence of adverse reactions of group LEU were compared with group GOS,and the difference was not statistically significant(P＞0.05).ConclusionFor patients with ovarian endometriosis,conservative operation combined with administration of GnRH-a would effectively increase the clinical efficacy and rates of successful pregnancy after treatment,alleviate symptom of dysmenorrhea,reduce the recurrence rates and incidence of adverse reactions.While the differences between Leuprorelin and Goserelin have no statistically significant.
凡连云;万贵平. 亮丙瑞林与戈舍瑞林对卵巢子宫内膜异位症术后复发及妊娠成功率的影响[J]. 中国当代医药, 2017, 24(30): 98-101.
FAN Lian-yun;WAN Gui-ping. Effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis operation. 中国当代医药, 2017, 24(30): 98-101.
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