无防腐剂自体血清眼水治疗飞秒激光准分子激光角膜原位磨镶术后干眼的临床效果

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摘要目的评价无防腐剂自体血清眼水治疗飞秒激光准分子激光角膜原位磨镶术（LASIK）后干眼的临床效果。方法选取2018年8月～2019年8月LASIK 后1 个月时诊断为中、重度干眼的42 例患者作为研究对象，按照随机数字表法将其分为对照组（21 例，42 眼）和实验组（21 例，42 眼）。对照组患者采用0.1%玻璃酸钠滴眼液点眼的常规治疗，实验组患者采用无防腐剂自体血清眼水治疗。局部点眼连续治疗28 d，于治疗后7、14、28 d 定期随访。对两组患者治疗前后的主观症状[采用眼表疾病指数（OSDI）评价]评分、泪膜破裂时间（BUT）、角膜荧光素染色评分、Schirmer I 试验结果进行记录分析，并观察两组的不良反应发生情况。结果治疗后14、28 d，实验组患者的OSDI 评分均低于对照组，差异有统计学意义（P＜0.05）。治疗后14、28 d，实验组患者的BUT 长于对照组，差异有统计学意义（P＜0.05）；治疗后7、14、28 d，实验组患者的角膜荧光素染色评分均低于对照组，差异有统计学意义（P＜0.05）。治疗后28 d，实验组的泪液分泌量多于对照组，差异有统计学意义（P＜0.05）。两组在治疗过程中均未见不良反应发生。结论无防腐剂自体血清滴眼液可安全、有效地治疗LASIK 后干眼患者，能促进角膜上皮修复、改善泪膜质量并有效缓解主观症状。

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	姚涛
	何伟

关键词 ：准分子激光角膜原位磨镶术, 干眼, 自体血清, 防腐剂

Abstract：Objective To evaluate the clinical effect of preservative-free autologous serum eye drops in the treatment of dry eyes after femtosecond laser-assisted in situ keratomileusis (LASIK). Methods Forty-two patients diagnosed with moderate to severe dry eyes from August 2018 to August 2019 one month after LASIK were selected as the research objects, and they were divided into the control group (21 cases, 42 eyes) and experimental group (21 cases, 42 eyes) according to the random number table method. Patients in the control group were treated with 0.1% Sodium Hyaluronate Eye Drops for routine treatment, and patients in the experimental group were treated with preservative-free autologous serum eye drops. Local eye drops were continuously treated for 28 days, and were followed up regularly at 7, 14, and 28 days after treatment. The subjective symptom (evaluated by the ocular surface disease index [OSDI]) score, tear break-up time (BUT), corneal fluorescein staining score, Schirmer I test results of the two groups of patients before and after treatment were recorded and analyzed. The incidence of adverse reactions of the two groups was observed. Results At 14 and 28 days after treatment, the OSDI scores of the patients in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). At 14 and 28 days after treatment, the BUT of the experimental group was longer than that of the control group, and the difference was statistically significant (P＜0.05). At 7, 14, and 28 days after treatment, the corneal fluorescein staining scores of the experimental group were lower than those of the control group, and the differences were statistically significant (P＜0.05). At 28 days after treatment,the amount of tears secreted in the experimental group was more than that in the control group, and the difference was statistically significant (P＜0.05). No adverse reactions occurred during the treatment in two groups. Conclusion Preservative-free autologous serum eye drops can safely and effectively treat dry eye patients after LASIK, promote corneal epithelial repair, improve the quality of tear film and relieve the subjective symptoms.

Key words： Laser-assisted in situ keratomileusis Dry eye Autologous serum Preservative

基金资助:辽宁省自然科学基金项目（2019-MS-257）

引用本文:

姚涛；何伟. 无防腐剂自体血清眼水治疗飞秒激光准分子激光角膜原位磨镶术后干眼的临床效果[J]. 中国当代医药, 2020, 27(19): 149-152.
YAO Tao；HE Wei. Clinical effect of preservative-free autologous serum eye drops in the treatment of dry eyes after femtosecond laser-assisted in situ keratomileusis. 中国当代医药, 2020, 27(19): 149-152.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I19/149

[1]	张志华，廉井财.准分子激光角膜原位磨镶术术后干眼症的研究进展[J].眼科研究，2010，28（9）：904-907.
[2]	中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识（2013年）[J].中华眼科杂志，2013，49（1）：73-75.
[3]	Ozcura F，Aydin S，Helvaci MR.Ocular surface disease index for the diagnosis of dry eye syndrome[J].Ocul Immunol Inflamm，2007，15（5）：389-393.
[4]	Stern ME，Beueman RW，Fox RI，et al.The pathology of dry eye：the interaction between the ocular surface and lacrimal glands[J].Cornea，1998，17（6）：584-589.
[5]	马子伟，韩伟，杨卫华，等.飞秒激光与传统LASIK 术后干眼参数变化[J].国际眼科杂志，2019，19（6）：924-928.
[6]	冯一帆，郁继国，施节亮，等.角膜瓣蒂位置对LASIK 术后干眼症发生率影响随机对照研究的Meta 分析[J].中华实验眼科杂志，2012，30（9）：847-852.
[7]	谢立信，史伟云.角膜病学[M].北京：人民卫生出版社，2007：48.
[8]	Melki SA，Azar DT.LASIK complications：etiology，management，and prevention[J].Surv Ophthalmol，2001，46（2）：95-116.
[9]	付梦军，王锐，张浩润，等.飞秒激光与机械板层刀制瓣的LASIK 术后干眼的临床对比研究[J].国际眼科杂志，2015，15（2）：215-218.
[10]	赵秀秀，赵少贞.飞秒激光与机械板层刀制瓣LASIK 对眼表影响的研究现状[J].眼科新进展，2014，34（3）：297-300.
[11]	Cho YK，Huang W，Kim GY，et al.Comparison of autologous serum eye drops with different diluents[J].Curr Eye Res，2013，38（1）：9-17.
[12]	Chung SH，Lee SK，Cristol SM，et al.Impact of short-term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin[J].Mol Vis，2006，12：415-421.
[13]	李骏，晏晓明.苯扎氯胺对体外培养的人角膜上皮细胞毒性作用的研究[J].眼科研究，2008，26（11）：814-817.
[14]	刘治容，张悦，吴峥峥，等.高浓度自体血清滴眼治疗眼表疾病[J].国际眼科杂志，2012，12（6）：1111-1113.
[16]	何宏，爱萍，郭颖卓，等.非单剂量自体血清滴眼治疗重度干眼的自身对照研究[J].国际眼科杂志，2012，12（8）：1478-1480.
[17]	曹林红，李威，王定保.自体血清滴眼液对翼状胬肉切除+自体角膜缘干细胞移植术患者预后的影响分析[J].当代医学，2019，25（19）：48-50.
[18]	Kojima T，Higuchi A，Goto E，et al.Autologous serum eye drops for the treatment of dry eye diseases[J].Cornea，2008，27：S25-S30.
[15]	Lekhanont K，Jongkhajornpong P，Choubtum L，et al.Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery[J].Biomed Res Int，2013，2013：521 315.
[19]	Geerling G，Maclennan S，Hartwig D.Autologous serum eye drops for ocular surface disorders[J].Br J Ophthalmol，2004，88（11）：1467-1474.