Diagnostic value of combined detection of serum tumor markers for gastric cancer
SUN Hui1 ZHU Li-jing1 WANG Zheng-qian
1.Department of Clinical Laboratory,Lianshui People′s Hospital Affiliated to Kangda College of Nanjing Medical University,Jiangsu Province,Lianshui 223400,China;
2.MRI Room,Lianshui People′s Hospital Affiliated to Kangda College of Nanjing Medical University,Jiangsu Province,Lianshui 223400,China
Abstract：Objective To evaluate the diagnostic value of several serum tumor markers in patients with gastric cancer by using receiver operating characteristic (ROC) curve. Methods A total of 57 patients with gastric cancer (group A),50 patients with benign gastric lesions (group B) and 50 healthy patients with normal gastric mucosa (group C) from January 2016 to December 2017 in our hospital were selected as the research objects.Expression levels of carcino embryonic antigen (CEA),carbohydrate antigen 72-4 (CA72-4),carbohydrate antigen 50 (CA50),carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 242 (CA242) in serum for the three groups were detected by electrochemiluminescence.ROC curve was carried for analysis. Results The expression levels of CEA,CA72-4,CA50,CA19-9 and CA242 in group A patients were higher than those in group B and group C,the differences were statistically significant(P<0.05).With the progress of gastric cancer staging,the positive detection rate of CEA,CA72-4,CA50,CA19-9 and CA242 in the serum of gastric cancer patients showed an increasing trend.When the tumor markers were detected individually,the AUC of CA19-9 was 0.777,and the sensitivity of CA72-4 was the highest,which was up to 77.7%.The diagnostic accuracy of combined detection of tumor markers was improved.The AUC of the combined detection of CA50,CA72-4,CA19-9 and CA242 was 0.925,and the sensitivity increased to 78.7%. Conclusion The combined detection of CA50,CA72-4,CA19-9 and CA242 can effectively improve the accuracy and sensitivity of diagnosis of gastric cancer patients,and has important clinical diagnosis and application value.
孙会;祝丽晶;王正前. 血清肿瘤标志物联合检测对胃癌的诊断价值[J]. 中国当代医药, 2020, 27(21): 4-7.
SUN Hui; ZHU Li-jing; WANG Zheng-qian. Diagnostic value of combined detection of serum tumor markers for gastric cancer. 中国当代医药, 2020, 27(21): 4-7.
Lin JX，Wang W，Lin JP，et al.Preoperative Tumor Markers Independently Predict Survival in Stage ⅢGastric Cancer Patients：Should We Include Tumor Markers in AJCC Staging?[J].Ann Surg Oncol，2018，25（9）：2703-2712.
Ghaderi B，Moghbel H，Daneshkhah N，et al.Clinical Evaluation of Serum Tumor Markers in the Diagnosis of Gastric Adenocarcinoma Staging and Grading[J].J Gastrointest Cancer，2019，50（3）：525-529.
京公网安备 11010502046607号