miRNA-34家族在宫颈癌中作用机制的研究进展

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Abstract

Cervical cancer is a malignant tumor that originates in the cervix.It is one of the most common malignant tumors that threaten women′s health in the world.Early symptoms are often not obvious.Despite using of advanced screening methods and preventive vaccines，the morbidity and mortality are still high in developing countries, so it is necessary to find new more effective molecular markers to further assist the diagnosis, treatment and prognosis cervical cancer.The miRNA-34 family plays an important role in the process of tumor cell proliferation, cycle regulation, apoptosis and aging, and it′s also a hotspot in cancer molecular targeted therapy.This article summarizes the molecular mechanism of miRNA-34 family in malignant tumors, and focuses on the role and research progress of miRNA-34 in cervical cancer.

Key words： microRNA miR-34 p53 Cervical cancer

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