预充羟乙基淀粉联合输注去氧肾上腺素预防剖宫产术中仰卧位综合征的临床效果

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Abstract Objective To explore the clinical effect of prefilled Hydroxyethyl starch combined with Phenylephrine infusion to prevent the occurrence of supine syndrome during cesarean section.Methods A total of 108 women accepting cesarean section admitted to Dongguan Shuixiang Central Hospital from April 2019 to April 2020 were selected.According to the random number table method,they were divided into three groups,A,B and C,with 36 cases in each group.In group A,compound sodium chloride injection in intravenous drip was used 30 min before anesthesia.In group B and C,intravenous drip of Hydroxyethyl starch 30 min before anesthesia was applied,and in group C,Phenylephrine was immediately added after successful anesthesia.The changes of systolic blood pressure (SBP),diastolic blood pressure (DBP) and heart rate (HR) of the three groups before anesthesia (T1),1 min after anesthesia (T2),3 min after anesthesia (T3),5 min after anesthesia (T4) and 10 min after anesthesia (T5),1 min and 5 min Apgar score of newborns,and incidence of supine syndrome during anesthesia were compared.Results There were no significant differences in SBP,DBP and HR indicators among the three groups at T1 (P>0.05).Compared with T1,the SBP of group A decreased at T3,T4,and T5,the SBP of group B decreased at T3 and T4,the SBP of group C increased at T3,the differences were statistically significant (P<0.05).Compared with T1,the DBP of group A decreased at T2,T3,and T4,the DBP of group B at T3,T4,and T5 decreased,the DBP of group C increased at T3,the differences were statistically significant (P<0.05).Compared with T1,the HR of group A increased at T2,T3,T4,and T5,the HR of group B increased at T3,T4,T5,the differences were statistically significant (P<0.05).Compared with T1,HR of group C was more stable at T2,T3,T4,T5,and the difference was not statistically significant (P>0.05).Compared with group A,the SBP of group B was higher at T4,in group C was higher at T3,T4,T5.The DBP in group B was higher at T4 and T5,and in group C was higher at T2,T3,T4,and T5.The HR in group B at T3 and T4 was lower and in group C,HR was lower at T2,T3,T4,and T5,the differences were statistically significant (P<0.05).Compared with group B,the SBP of group C increased at T2,T3,T4,and T5 and the DBP of group C was higher at T2,T3,and T4,and the HR of group C was lower at T2,T3,and T4,the differences were statistically significant (P<0.05).The 1 min Apgar score of newborns in group C was higher than that of group A and B,and the differences were statistically significant (P<0.05).5 min Apgar score was higher than that of 1 min in all three groups,and the differences were statistically significant (P<0.05).There was no statistical difference in 5 min Apgar score of the three groups (P>0.05).There was no significant difference in Apgar score between group A and B at 1 min and 5 min (P>0.05).The incidence of supine syndrome in the group C was lower than that of the A and B group,the differences were statistically significant (P<0.05).Conclusion The prefilled Hydroxyethyl starch combined with Phenylephrine infusion for cesarean parturient women has a remarkable effect on preventing the occurrence of supine syndrome,which can effectively improve the blood pressure and reduce the incidence of supine syndrome,and incrase the Apgar score of newborns.It can protect the safety of mother and child and is worthy of clinical promotion.

Key words： Supine syndrome Hydroxyethyl starch Phenylephrine Cesarean section

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	HU Ming-xiu
	YU Wang-jun
	ZHOU Liu-yu
	WU Gang
	CHEN Ru-kang

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HU Ming-xiu,YU Wang-jun,ZHOU Liu-yu, et al. Clinical effect of prefilled Hydroxyethyl starch combined with Phenylephrine infusion to prevent supine syndrome during cesarean section[J]. 中国当代医药, 2021, 28(4): 137-140.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I4/137

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