Slug和Vimentin在甲状腺乳头状癌中表达及其与患者临床病理特征的关系研究

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Abstract Objective To explore the expression and correlation of Slug and Vimentin in papillary thyroid carcinoma(PTC). Methods A total of 103 PTC patients′ cancer tissue samples in People′s Hospital of Binzhou City from January 2011 to January 2020 were selected as the research group.In the same period,42 cases of PTC adjacent tissue samples were selected as the control group.The expressions of Slug and Vimentin in two groups were analyzed by immunohistochemistry,and the relationship between Slug and Vimentin and clinicopathological parameters was analyzed. Results The positive rates of Slug and Vimentin in the research group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The positive rates of Slug and Vimentin in extrathyroidal invasion tissues were higher than those in no extrathyroidal invasion tissues,and the differences were statistically significant (P＜0.05).The positive rates of Slug and Vimentin in later TNM stage tissues were higher than those in earlier TNM stage tissues,and the differences were statistically significant (P＜0.05).The positive rates of Slug and Vimentin in lymph node metastasis tissues were higher than those in no lymph node metastasis tissues,and the differences were statistically significant (P＜0.05).There was positive correlation between Slug and Vimentin in PTC (r=0.523,P=0.031). Conclusion The abnormal expressions of Slug and Vimentin gene may promote PTC invasion and metastasis,which can provide a reliable basis for clinical diagnosis and treatment assessment.

Key words： Thyroid neoplasm Slug Vimentin Immunohistochemistry

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	Articles by authors
	XUE Dong
	LI Meng-yu
	DING Bao-zhong
	SONG Xiang-kong
	XIA Xiu-liang

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XUE Dong,LI Meng-yu,DING Bao-zhong, et al. Expression of Slug and Vimentin in papillary thyroid carcinoma and study on their relationship with clinicopathological features[J]. 中国当代医药, 2021, 28(7): 4-7.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I7/4

[1]	Lundgren CI，Hall P，Dickman PW，et al.Clinically significant prognostic factors for differentiated thyroid carcinoma：a population-based，nested case-control study[J].Cancer，2006，106：524-531.
[11]	俞立萍，邓周峰，万剑慧，等.波形蛋白、锌指蛋白在非小细胞肺癌组织中的表达变化及其相互关系[J].山东医药，2019，59（14）：69-71.
[2]	Sun W，Lan XB，Zhang H，et al.Risk factors for central lymph node metastasis in CN0 papillary thyroid carcinoma：a systematic review and Meta-analysis[J].PLoS One，2015，10（10）：e0139021.
[3]	Bastid J.EMT in carcinoma progression and dissemination：facts，unanswered questions，and clinical considerations[J].Cancer Metastasis Rev，2012，31（1-2）：277-283.
[4]	Andreiana BC，Stepan AE，Taisescu O，et al.Immunoexpression of Snail，Twist 1 and Slug in clear cell renal cell carcinoma[J].Rom J Morphol Embryol，2019，60（2）：463-468.
[5]	Kihara A，Wakana K，Kubota T，et al.SLUG expression is an indicator of tumour recurrence in high-grade endometrial carcinomas[J].Histopathology，2016，69（3）：374-382.
[6]	Cho YA，Kim EK，Cho BC，et al.Twist and Snail/Slug expression in oropharyngeal squamous cell carcinoma in correlation with lymph node metastasis[J].Anticancer Res，2019，39（11）：6307-6316.
[7]	Odero-Marah V，Hawsawi O，Henderson V，et al.Epithelialmesenchymal transition （EMT） and prostate cancer[J].Adv Exp Med Biol，2018，1095：101-110.
[8]	Liu CY，Lin HH，Tang MJ，et al.Vimentin c ontributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation[J].Oncotarget，2015，6（18）：15 966-15 983.
[9]	Du L，Li JC，Lei L，et al.High vimentin expression predicts a poor prognosis and progression in colorectal cancer：a study with Meta-analysis and TCGA database[J].Biomed Res Int，2018，2018：6387810.
[10]	Tran B，Roshan D，Abraham E，et al.An analysis of the American joint committee on cancer 8thedition T staging system for papillary thyroid carcinoma[J].J Clin Endocrinol Metab，2018，103（6）：2199-2206.
[12]	Lee YM，Park JH，Cho JW，et al.The definition of lymph node micrometastases in pathologic N1α papillary thyroid carcinoma should be revised[J].Surgery，2019，165（3）：652-656.
[13]	Pastushenko I，Blanpain C.EMT Transition States during Tumor Progression and Metastasis[J].Trends Cell Biol，2019，29（3）：212-226.
[14]	Li XN，Fang CQ，Wang YL，et al.Slug regulates E-cadherin expression in metastatic adenocarcinoma cells isolated from pleural fluid[J].Diagn Cytopathol，2013，41（1）：9-14.
[15]	Wu Q，Zhou L，Yang Y，et al.Correlation of Wnt antagonist sFPR1，Slug and β-catenin with prognosis and metastasis in colorectal carcinoma[J].Int J Clin Exp Pathol，2018，11（1）：269-280.
[16]	雍翔，宋瑞，胡怀远，等.食管鳞状细胞癌中SOX2 和Slug的表达及与肿瘤出芽之间的关系[J].中国组织化学与细胞化学杂志，2019，28（3）：236-241.
[17]	Shakib H，Rajabi S，Dehghan MH，et al.Epithelial-to-mesenchymal transition in thyroid cancer：a comprehensive review[J].Endocrine，2019，66（3）：435-455.
[18]	Lu W，Luo JY，Wu MH，et al.Expression of vimentin in nasopharyngeal carcinoma and its possible molecular mechanism：a study based on immunohistochemistry and bioinformatics analysis[J].Pathol Res Pract，2019，215（5）：1020-1032.
[19]	Bhardwaj M，Sen S，Chosdol K，et al.Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma[J].Br J Ophthalmol，2020，104（6）：879-884.