血清鳞状细胞癌抗原、糖链抗原125、糖链抗原199水平表达对宫颈小细胞癌患者预后的评估价值

Abstract
Figure/Table
References (16)
Related Citation (0)

Download: PDF (0 KB) HTML (32 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore evaluation value of expression of serum squamous cell carcinoma antigen (SCC), carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) for prognosis of patients with small cell carcinoma of cervix (SCCC).Methods A total of 58 patients diagnosed with SCCC in Dalian Maternal and Child Health Hospital from January 2018 to January 2019 were enrolled as the observation group, and 58 healthy women who underwent physical examination during the same period were enrolled as the control group.The levels of SCC, CA125 and CA199 in the control group and in the observation group before and after treatment were detected.According to different prognosis, the SCCC patients were divided into effective treatment group and ineffective treatment group, and the levels of SCC, CA125 and CA199 were compared between the two groups.Results The levels of SCC, CA125 and CA199 in observation group before and after treatment were higher than those in control group, and the differences were statistically significant (P＜0.05).At the fourth month after discharge, of the 58 SCCC patients, there were 36 cases with effective treatment, and 22 cases with ineffective treatment.The levels of SCC, CA125 and CA199 in the ineffective treatment group were higher than those in the effective treatment group, and the differences were statistically significant (P＜0.05).The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of the combined detection of SCC, CA125, and CA199 was larger than that of SCC, CA125, and CA199 alone, and the difference was statistically significant (P＜0.05).Conclusion Serum SCC, CA125, CA199 are of relatively higher diagnostic value for SCCC, which can be applied as indexes for prognosis evaluation.

Key words： Small cell carcinoma of cervix Squamous cell carcinoma antigen Carbohydrate antigen 125 Carbohydrate antigen 199

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Qi
	WANG Nan
	LIU Dan

Cite this article:

WANG Qi,WANG Nan,LIU Dan. Evaluation value of serum squamous cell carcinoma antigen, carbohydrate antigen 125 and carbohydrate antigen 199 expression for prognosis of patients with small cell carcinoma of cervix[J]. 中国当代医药, 2020, 27(8): 169-171.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I8/169

[1]	章家青.宫颈癌患者血清中SCC-Ag 含量与肿瘤恶性生物学行为的关系[J].实用预防医学，2019，26（2）：238-241.
[2]	宋柯琦，狄文.妊娠合并宫颈疾病诊治进展[J].国际妇产科学杂志，2017，44（3）：356-360.
[3]	尼华，牛蕾蕾，景兰凯，等.宫颈原发性小细胞癌5例分析[J].中国微创外科杂志，2017，17（11）：1007-1010.
[4]	闫华，姚田，李小平，等.宫颈恶性肿瘤血清肿瘤标记物谱变化的临床意义[J].现代妇产科进展，2018，27（7）：536-538.
[5]	高琳，王佐君，张玲，等.HPV-DNA 分型与血清SCC-Ag、CA125 联合检测在宫颈癌早期诊断中的价值[J].中国妇幼保健，2018，33（24）：5953-5956.
[6]	支文雪，石素胜.宫颈小细胞癌临床病理研究[J].诊断病理学杂志，2016，23（3）：179-182.
[7]	杨楠.宫颈小细胞癌患者临床病理特征及预后影响因素分析[J].中国综合临床，2018，34（2）：165-169.
[8]	袁馨，沈扬眉，赵霞.宫颈小细胞癌与非小细胞癌临床特征及预后的对比研究[J].实用妇产科杂志，2017，33（4）：281-285.
[9]	杜靖然，王妍，杨永秀.宫颈小细胞癌非手术治疗研究进展[J].国际妇产科学杂志，2018，45（4）：460-463.
[10]	童英，谢青梅，吴倩，等.宫颈小细胞癌临床病理分析[J].贵州医药，2018，42（3）：342-343.
[11]	杨丹，洪莉.宫颈小细胞癌的临床病理分析[J].中国计划生育和妇产科，2016，8（6）：46-50，55.
[12]	路会侠，李绍波.宫颈癌相关肿瘤标志物的检测进展[J].医学综述，2017，23（23）：4638-4643.
[13]	王晓娟，散琴，王月明，等.CEA、CA125、SCC-Ag、CA199及CYFRA211 等肿瘤标志物在宫颈癌中诊断的价值和意义[J].海南医学院学报，2017，23（18）：2573-2576.
[14]	王若琪，韩菲菲.CA125、CA153、CA199和SCC 联合检测对宫颈癌的诊断价值[J].实用癌症杂志，2016，31（11）：1744-1746.
[15]	张蕾，曾凡清.血清中SCC-Ag、CEA和CA125 联合检测在宫颈癌诊断中的意义[J].中国实验诊断学，2017，21（10）：1708-1710.
[16]	陈玉芬，韩敏，张秀俊，等.血清miR-155 联合HE4、CA199诊断子宫内膜癌的价值[J].中国医药导报，2019，16（20）：100-103.