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Abstract Objective To prepare Orally Disintegrating Tablets (ODT) of Compound Salvia Miltiorrhiza by three dimensions (3D) printing technology and make a preliminary evaluation.Methods Salvia Miltiorrhiza, Panax Notoginseng,Borneol, lactose, povidone K30, mannitol, aspartame, and silicon dioxide were mixed and used as the printing powders,and alcohol aqueous solution containing 2% PVP K30 was used as the binder.ODT of Compound Salvia Miltiorrhiza was prepared by 3D printing technology.The ODT was set 5 mm in radius, 0.1 mm in coating layer height, and 30 layers in layer number.Then the disintegration time, hardness, weight, taste, appearance, and internal structure of the ODT were detected.Results The ODT radius of Compound Salvia Miltiorrhiza was about (5.1±0.1) mm in radius, the thickness was (3.2±0.2) mm.The average mass of the tablets was 167.6 mg (RSD=3.40%) and the hardness of the tablets was (1.72±0.20) kg.The prepared tablets disintegrated within 1 min, with high porosity, good appearance and taste, slightly sweet.The results of scanning electron microscopy indicated that the microstructure of the tablets was uniform.Conclusion The 3D printed ODT of Compound Salvia Miltiorrhiza has high porosity, simple process, short disintegration time, good taste and appearance.It shows that 3D printed ODT of Compound Salvia Miltiorrhiza is feasible to some extent.

Key words： 3D printing Compound Salvia Miltiorrhiza Orally Disintegrating Tablets Disintegration time Hardness

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	Articles by authors
	LI Yue-zhong
	TANG Liang
	YANG Ya-dong
	ZHANG Wen-yuan

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LI Yue-zhong,TANG Liang,YANG Ya-dong, et al. Preparation technology and preliminary evaluation of Orally Disintegrating Tablets of Compound Salvia Miltiorrhiza by three dimensions printing[J]. 中国当代医药, 2019, 26(12): 48-51.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I12/48

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