复方中药组分对链脲菌素糖尿病大鼠糖耐量的影响

Abstract
Figure/Table
References (16)
Related Citation (6)

Download: PDF (0 KB) HTML (33 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the preventive and therapeutic effects of compound Chinese medicine components on diabetes mellitus (DM), and to explore its prevention and treatment mechanism.Methods The rat model of DM was induced by intraperitoneal injection of streptozotocin administered at a dose of 55 mg/kg.After a successful modeling, a total of 40 rats were randomly assigned into the blank control group, the model control group and the drug intervention group (the high-dose drug intervention group, the low-dose drug intervention group), 10 cases in each group.The drug intervention group was treated with high- and low-dose of compound Chinese medicine components, the blank control group and the model control group were intragastrically administered with normal saline per day according to the weight standard of 10 ml/kg.The levels of fasting blood glucose (FBG), glucose tolerance, superoxide dismutase (SOD) activity and malondialdehyde (MDA) in pancreas were observed.Results The level of blood glucose of the model control group was significantly higher than that of the blank control group (P＜0.001).The levels of blood glucose at 0.0, 0.5, 1.0, 2.0 h of the drug intervention group were significantly lower than those of the model control group (P＜0.05).The levels of glucose tolerance of the model control group were significantly lower than those of the blank control group, the levels of glucose tolerance for some time of the compound Chinese medicine component intervention group in a large dose administration were significantly higher than those of the model control group.The level of SOD of the model control group was significantly lower than that of the blank control group, and the MDA of the model control group was higher than that of the blank control group, the level of SOD of the high-dose intervention group was significantly higher than that of the model control group, the level of MDA of the high-dose drug intervention group was greatly lower than that of the model control group (P＜0.01).The level of SOD of the low-dose drug intervention group was higher than that of the model control group, with statistical difference (P＜0.05).The MDA in the low-dose drug intervention group was much lower than that in the model control group, with statistical significance (P＜0.01).Conclusion Compound Chinese herbal medicines have preventive and therapeutic effects on diabetes mellitus.

Key words： Compound Chinese medicine components Antioxidant Glucose tolerance

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Xin
	HUANG Bo
	LIU Yong-lin
	FENG Yao
	LIU Ming-hu
	ZHANG He
	SONG Guang-yi
	LIU Wen-yan

Cite this article:

YANG Xin,HUANG Bo,LIU Yong-lin, et al. Influence of compound Chinese medicine components on glucose tolerance in streptozotocin-induced diabetic rats[J]. 中国当代医药, 2019, 26(12): 45-47.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I12/45

[9]	梁峰，胡大一，沈珠军.2014 美国糖尿病指南：糖尿病诊疗标准[J].中华临床医师杂志（电子版），2014，8（6）：151-159.
[10]	安梅，周瑾，陈晓宇.白藜芦醇药理学作用的研究进展[J].肿瘤药学，2014，4（4）：242-246.
[11]	谷雨明，黄延芹，徐云生.现代中医治疗糖尿病的辨证体系研究进展[J].河北中医，2015，37（10）：1587-1589.
[12]	陆菊明.预混胰岛素在糖尿病治疗中的应用—2010年《中国2 型糖尿病防治指南》解读[J].中华糖尿病杂志，2011，3（2）：187-189.
[1]	雷定超，张兰兰，周水平，等.中药治疗糖尿病现状与研究进展[J].中国医药导报，2012，9（21）：8-9，12.
[2]	宋光熠，姜雅秋，李屹，等.二多糖胶囊对实验性糖尿病大鼠血糖的影响[J].吉林医学，2007，28（15）：1685-1686.
[6]	李屹，张建军.海鞘对实验性糖尿病大鼠非酶糖基化的影响[J].辽宁医学院学报，2008，29（2）：125-127.
[7]	刘文艳，刘晓苏.复方中药组分抗糖尿病大鼠糖过氧化作用[J].中国老年学杂志，2013，33（20）：5026-5027.
[8]	车光升，宋光熠.海鞘对糖尿病大鼠血浆内皮素-1 影响[J].中国公共卫生，2009，25（5）：571-572.
[3]	Clarke WL，Cox D，Gonder-Frederick LA，et al.Evaluating clinicalaccuracy of systems for self-monitoring of blood glucose[J].Diabetes Care，1987，10（5）：622-628.
[4]	Weinstein RL，Schwartz SL，Brazg RL，et al.Accuracy of the 5-day Free Style Navigator continuous glucose monitoring system comparison with frequent laboratory reference measurements[J].Diabetes Care，2007，30（5）：1125-1130.
[5]	张娴，刘莉.白藜芦醇粉对2 型糖尿病患者血糖及超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）的影响[J].河北中医，2017，39（1）：19-22.
[13]	金萍，陈涛，石秀娥，等.外周血指标检测在动脉粥样硬化性脑梗死中的应用研究[J].国际检验医学杂志，2017，38（11）：143-145.
[14]	王敏.糖耐量减低与动脉粥样硬化相关性的研究进展[J].医学诊断，2015，5（1）：1-5.
[15]	陈涛，石秀娥，王一萍，等.糖耐量异常人群血清hs-CRP、Hcy、CysC 水平与颈动脉粥样硬化的相关性研究[J].国际检验医学杂志，2018，39（15）：1838-1841.
[16]	刘晶晶，林桂明，王丽颖，等.PDTC 通过抑制NF-κB 及Wnt/β-catenin 信号通路修复1 型糖尿病大鼠主动脉病变[J].中国药理学通报，2018，34（11）：1622-1627.