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| Influence of different gestational weeks of hypoglycemic therapy on maternal and fetal outcomes in patients with gestational diabetes |
| XU Bo CHEN Ping CHEN Yuan YANG Dong-qun |
| Department of Obstetrics, Maternal and Child Health Family Planning Service Center of Huizhou City in Guangdong Province, Huizhou 516001, China |
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Abstract Objective To explore the influence of different gestational weeks of hypoglycemic therapy on maternal and fetal outcomes in patients with gestational diabete (GDM). Methods A total of 86 patients with GMD who were treated and delivered in our hospital from December 2016 to June 2018 were selected as subjects, 43 patients who received insulin aspartate before 30 weeks of gestation were selected as the observation group, 43 cases of insulin asparts started after 30 weeks were selected as the control group. The blood glucose levels included fasting blood glucose (FPG) and postprandial 2 h blood glucose (2 h PG), homocysteine (Hcy), cystatin C ( Cys-C) changes of the two groups were observed. The maternal and child outcomes of the two groups were compared. Results Before childbirth, the levels of FPG, 2 h PG, Hcy and Cys-C in the two groups were lower than those before treatment, the difference was statistically significant (P＜0.05). There was no significant difference in the levels of FPG, 2 h PG, Hcy and Cys-C before childbirth between the two groups (P＞0.05). The incidence of hypoglycemia, polyhydramnios, hypertension in pregnancy and postpartum hemorrhage in the observation group was lower than that in the control group, with significant difference (P＜0.05). The incidence of neonatal macrosomia, low birth weight, neonatal ventricular suffocation, hyperbilirubinemia and neonatal hypoglycemia in the observation group was lower than that in the control group, and the above differences were statistically significant (P＜0.05). Conclusion The use of insulin aspart in the early pregnancy and the third trimester of pregnancy to control blood glucose is equivalent, but the intervention of blood glucose levels in early pregnancy can significantly improve the maternal and child outcomes of GDM patients.
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