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| Effect of Capecitabine combined with radiotherapy on elderly patients with advanced esophageal cancer |
| LI Ji-yuan SUN Qin-wen HONG Feng-juan CHEN Jian CHEN Yan-zhen |
| Department of Oncology, Yangchun People′s Hospital, Guangdong Province, Yangchun 529600, China |
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Abstract Objective To investigate the effect of Capecitabine combined with radiotherapy in the treatment of elderly patients with advanced esophageal cancer. Methods A total of 76 elderly patients with advanced esophageal cancer admitted to our hospital from March 2013 to July 2015 were selected as the study subjects, they were divided into control group (38 cases) and observation group (38 cases) according to random number table method. The control group was treated with radiotherapy, while the observation group was treated with Capecitabine combined with radiotherapy, the course of treatment in both groups was 6 weeks. The clinical efficacy, adverse reactions and survival within 3 years after treatment were compared between the two groups. Results The total effective rate of the observation group (73.68%)was higher than that of the control group (50.00%), the difference was statistically significant (P＜0.05). The 1-year survival rate of the patients in the observation group (84.21%) was higher than that in the control group (60.53%), the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Capecitabine combined with radiotherapy in the treatment of elderly patients with advanced esophageal cancer has a remarkable effect. It can effectively alleviate the patient′s condition and improve the survival rate of patients. Moreover, the treatment method has a high safety, and minor adverse reactions do not affect the remission of patients'condition. It is worthy of wide application in clinical treatment.
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