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| Application effect of Thymopentin combined with Oxaliplatin and Capecitabine in adjuvant chemotherapy for patients with rectal cancer |
| HUANG Shui-xian1 CAI Xu-jie2 WU Jiang-hong3 LAI Zhen-miao1 |
| 1. Department of Pharmacy, People′s Hospital of Yingde City, Guangdong Province, Yingde 513000, China; 2. Department of Oncology, Yingde People′s Hospital of Guangdong Province, Yingde 513000, China; 3. Department of Oncology, Yingde Hospital of Tradition Chinese Medicine of Guangdong Province, Yingde 513000, China |
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Abstract Objective To investigate the application effect of Thymopentin combined with Oxaliplatin and Capecitabine in adjuvant chemotherapy for patients with rectal cancer. Methods Fifty patients with rectal cancer admitted to Yingde People′s Hospital from August 2016 to June 2018 were selected as the study subjects, they were divided into control group and observation group according to random number table method, with 25 cases in each group. The control group was treated with Oxaliplatin combined with Capecitabine, while the observation group was treated with Thymopentin on the basis of the control group. The blood routine and quality of life scores were compared between the two groups. Results The leucocyte count in the observation group was significantly higher than that in the control group, the difference was significant (P＜0.05). After chemotherapy, the scores of mood, sleep and appetite in the observation group were significantly lower than those in the control group, and the KPS scores were significantly higher than those in the control group, the differences were significant (P＜0.05). Conclusion Chemotherapy with Thymopentin combined with Oxaliplatin and Capecitabine can significantly improve the quality of life of patients with rectal cancer and the bone marrow suppression caused by chemotherapy.
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