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| Effect comparison of Diazepam,Phenobarbital and Midazolam in the treatment of pediatric convulsions |
| HUANG Shi-xuan YANG Xue-qun FANG Chun-hua |
| Department of Emergency,Shijie Hospital in Dongguan City,Guangdong Province,Dongguan 523290,China |
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Abstract Objective To investigate the efficacy of Diazepam,Phenobarbital and Midazolam in the treatment of convulsions in children.Methods A total of 90 children with pediatric convulsions treated in our hospital from November 2015 to November 2017 were selected as subjects.The children were divided into Phenobarbital group,Diazepam group and Midazolam group according to the difference in the order of treatment,30 cases in each group.The Phenobarbital group was treated with Phenobarbital,the Diazepam group was treated with Diazepam,and the Midazolam group was treated with Midazolam.The clinical treatment effects,drug onset time,and incidence of adverse reactions were compared of children in three groups.Results The total effective rate of clinical treatment of children in the Midazolam group was 90.00%,which was significantly higher than that in the Diazepam group(63.33%)and Phenobarbital group(73.33%),the differences were statistically significant(P＜0.05).The average onset time of drug of children in the Midazolam group was significantly shorter than that in the Phenobarbital group and Midazolam group,and the differences were statistically significant(P＜0.05).The overall incidence of adverse reactions of children in the Midazolam group(6.67%)was significantly lower than that in the Midazolam group(30.00%)and Phenobarbital group(26.67%),the differences were statistically significant(P＜0.05).Conclusion Children with convulsion received treament by Diazepam,Phenobarbital and Midazolam,both of which had certain therapeutic effects.However,the clinical effect of Midazolam is better,the incidence of adverse reactions is low,and the clinical effect is significant,which is worthy of being popularized.
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| [1] |
刘永昌.苯巴比妥、地西泮、咪达唑仑治疗小儿惊厥的临床效果对比分析[J].医学理论与实践，2017，30（3）：411-412.
|
| [2] |
邱名才.不同治疗方案对小儿惊厥性癫痫持续状态的疗效比较[J].中国实用神经疾病杂志，2016，19（11）：83-84.
|
| [3] |
吴凤霞.咪达唑仑治疗小儿惊厥持续状态的效果分析[J].中国卫生标准管理，2016，7（20）：136-137.
|
| [4] |
袁强.咪达唑仑在小儿癫痫持续状态中的应用效果[J].安徽医药，2016，20（12）：2259-2261.
|
| [5] |
阿依江·木拉提汗，马文强.不同镇静药在小儿急性惊厥中的疗效对比[J].包头医学院学报，2016，32（5）：96-97.
|
| [6] |
王婉霞.儿童腰椎穿刺术应用咪达唑仑与地西泮效果比较[J].包头医学院学报，2016，32（1）：70-71.
|
| [7] |
黄玲.氯硝安定肌内注射和灌肠治疗小儿惊厥的疗效观察[J].中国中西医结合儿科学，2015，7（5）：445-447.
|
| [8] |
李蜀.地西泮联合苯巴比妥治疗小儿惊厥的临床分析[J].中国处方药，2016，14（4）：52-53.
|
| [9] |
李俊标.咪达唑仑治疗婴幼儿重症病毒性脑炎惊厥持续状态 34 例疗效观察[J].中国民族民间医药，2016，25（11）：95.
|
| [10] |
黄静，邓静.地西泮联合苯巴比妥治疗小儿惊厥的临床效果[J].中国医药导报，2017，14（21）：129-132.
|
| [11] |
林燕，陈邓，陈涛，等.咪达唑仑非静脉途径治疗儿童癫痫持续状态有效性和安全性的Meta分析[J].中国现代神经疾病杂志，2016，16（2）：79-86.
|
| [12] |
郭志磊，范捷，于洋.固相萃取-高效液相色谱法同时测定人血浆中地西泮、咪达唑仑及其代谢产物的浓度和临床应用[J].中国医院药学杂志，2016，36（10）：825-829.
|
| [13] |
田凯，骆媛，李万华，等.咪达唑仑经鼻给药在最大电休克发作及戊四唑惊厥模型的抗惊厥作用[J].军事医学，2015，39（5）：368-372.
|
| [14] |
曹琳.复方小儿退热栓治疗小儿高热惊厥的临床效果[J].中国当代医药，2016，23（8）：87-88.
|
| [15] |
蓝海燕.咪达唑仑在NICU机械通气中的临床价值[J].中国医药科学，2016，6（10）：35-37.
|
| [16] |
皮贵荣，段胜稳，方桂华.安定联合苯巴比妥治疗小儿惊厥的临床效果[J].中国医药科学，2016，6（12）：46-48.
|
| [17] |
尚振刚.地西泮舌下滴服治疗小儿惊厥31例疗效观察[J].河北北方学院学报（自然科学版），2017，33（6）：25-26.
|
| [18] |
单雪峰，帕如克，马松峰.不同药物治疗小儿高热惊厥复发的临床效果对比[J].临床医学研究与实践，2016，1（10）8.
|
| [19] |
肖艺，龙喻，刘瑛.轻度胃肠炎伴婴幼儿良性惊厥与热性惊厥血清和脑脊液锌水平比较[J].临床和实验医学杂志，2017，16（22）：2265-2267.
|
| [20] |
林冠，杨志荣.他汀类药物对癫痫的作用进展及机制研究[J].临床和实验医学杂志，2016，15（17）：1756-1759.
|
|
|
|
