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| The influence of Lidocaine on the perioperative stress reaction and immunologic function in patients undergoing cervical lymph node tuberculosis resection |
| ZHOU Tian-tian1 CHEN Zi-yang2 YU Shu-xia1 ZHANG Shao-gang1▲ |
1.Department of Anesthesiology,Affiliated Nanjing Integrated Traditional Chinese and Western Medicine Hospital of Nanjing Traditional Chinese Medicine University,Jiangsu Province,Nanjing 210014,China;
2.Department of Anesthesiology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province,Nanjing 210029,China |
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Abstract ObjectiveTo observe the influence of Lidocaine on the perioperative stress response and immunologic function in patients undergoing cervical lymph node tuberculosis resection.MethodsSixty patients scheduled for cervical lymph node tuberculosis resection from August 2016 to June 2017 in our hospital were selected.The patients were divided into Lidocaine group(group L)and control group(group C)according to the random number table method,and there were 30 patients in each group.Group L was administered 1.5 mg/kg bolus dose of Lidocaine before 10 min tracheal intubation,followed by 1.5 mg/（kg·h） infusion until the end of operation while group C was continuously pumped the equal capacity of normal saline.MAP,HR were recorded before 30 min anesthesia induction(T0),after 1 h operation initiation(T1),immediately after operation(T2),after 6 h operation(T3).Enzyme-linked immunosorbent assay was used to detect norepinephrine (NE),epinephrine (E),cortisol(Cor)at T0-T3.Flow cytometry was used to detect T lymphocytes(CD3+,CD4+,CD8+,CD4+/CD8+)and NK cells at T0-T3.ResultsCompared to those at T0,MAP,HR and stress hormones(NE,E,Cor)in both groups were significantly increased at T1-T3(P＜0.05),which was more significant in group C than that of group L(P＜0.05).The level of CD3+,CD4+,CD8+,CD4+/CD8+at T1-T3were significantly lower in both groups,and the levels in group C were obviously lower than those in group L(P＜0.05).The level of NK cells was higher at T1-T3in both groups,the level in group L was obviously higher than those in group C(P＜0.05).ConclusionIntravenous infusion of Lidocaine can suppress perioperative stress reaction effectively and reduce the influence on immunologic function of cell.
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