|
|
Application value of T cell spot test in the diagnosis of extrapulmonary tuberculosis |
GONG Mi1 LU Ying2 |
1.Hepatology Institute,the Third People′s Hospital of Shenzhen City,Shenzhen 518040,China;
2.Department of Clinical Laboratory,the 401stHospital of PLA,Shandong Province,Qingdao 266071,China |
|
|
Abstract ObjectiveTo discuss the diagnostic value of T cell spot test in the diagnosis of pulmonary tuberculosis.Methods200 cases of suspected pulmonary tuberculosis from January 2013 to August 2016 in our hospital were selected as the object of study review,all patients were detected by T cell spot test and tuberculosis antibody detection, clinical diagnosis result was set as reference,the diagnostic sensitivity,specificity and accuracy of extrapulmonary tuberculosis were calculated and compared between tuberculosis antibody and T cell spot test.ResultsThe diagnostic sensitivity,specificity and accuracy of T cells spot test in extrapulmonary tuberculosis were 96.45%,93.55%and 96.00%,and compared with the sensitivity(53.85%),specificity(64.52%)and accuracy(55.50%)in the diagnosis of tuberculosis antibody detection,the difference was statistically significant(P<0.05).The consistency between the results of the T cell spot test for the diagnosis of extrapulmonary tuberculosis and the clinical outcome was Kappa=0.725,and the agreement between the results of TB antibody detection and clinical diagnosis was Kappa=0.435.ConclusionThe T cell spot test can be used for rapid and accurate diagnosis of pulmonary tuberculosis,it has significant diagnostic value in the diagnosis of pulmonary tuberculosis,which can be used as an important auxiliary diagnosis method for the diagnosis of pulmonary tuberculosis.
|
|
|
|
|
[1] |
田洹,胡文斌,毛艳军,等.结核感染T细胞斑点试验对肺外结核诊断的临床意义[J].国际检验医学杂志,2016,37(1):114-115.
|
[2] |
Cho OH,Park KH,Kim SM,et al.Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to the site of infection[J].J Infection,2011,63(5):362-369.
|
[3] |
刘晓莺,樊海燕,叶绥艳,等.T细胞斑点试验在肺外结核诊断中价值[J].现代仪器与医疗,2016,22(4):53-55.
|
[5] |
钟一鸣,谷秀梅,刘文恩,等.T细胞斑点试验辅助诊断不同部位肺外结核感染的应用[J].中华医院感染学杂志,2014,24(17):4415-4417.
|
[6] |
王成勇,潘士虎,刘敏,等.结核感染T细胞斑点试验与荧光定量 PCR在肺外结核诊断中的应用[J].国际检验医学杂志,2015,36(14):1998-1999.
|
[4] |
Lee YM,Park KH,Kim SM,et al.Risk factors for false-negative results of T-SPOT.TB and tuberculin skin test in extrapulmonary tuberculosis[J].Infection,2013,41(6):1089-1095.
|
[7] |
孙雯雯,肖和平,吴福蓉,等.结核感染T细胞斑点试验在临床诊断为肺外结核患者中的价值评价[J].中国防痨杂志,2015,37(7):784-789.
|
[8] |
舒晋峰,许小敏.结核感染T细胞斑点试验对肺外结核诊断价值探讨[J].中国微生态学杂志,2013,25(12):1444-1446,1450.
|
[9] |
王立红,付秀华,张桂芝,等.结核感染T细胞斑点试验在结核病诊断中的应用价值[J].中国防痨杂志,2013,35(12):992-996.
|
[10] |
应晓,王振华,吴惠芬,等.T细胞斑点试验在肺结核诊断中的应用价值[J].检验医学,2016,31(5):433-434.
|
[11] |
陶学芳,王建华,李永兴,等.结核感染T细胞酶联免疫斑点试验在肺结核及肺外结核诊断中的价值[J].浙江预防医学,2012,24(11):4-7.
|
[12] |
于丹,刘宁.结核感染T细胞斑点试验在疑似结核病患者诊断中的价值[J].热带医学杂志,2016,16(1):45-47,54.
|
[13] |
崔鲂,杨玲,孟江萍,等.结核感染T细胞斑点试验及结核抗体在肺外结核病诊断中的临床意义[J].西部医学,2014,26(1):103-104,107.
|
[14] |
刘红,黄永杰,王静,等.结核感染T细胞斑点试验在疑似结核病患者诊断中的价值研究[J].中华结核和呼吸杂志,2014,37(3):192-196.
|
[15] |
Soysal A,Toprak D,Koc M,et al.Diagnosing latent tuberculosis infection in haemodialysis patients:T-cell based assay(T-SPOT.TB)or tuberculin skin test?[J].Nephrol Dial Transplant,2012,27(4):1645-1650.
|
|
|
|