重组人脑利钠肽联合低分子肝素钙治疗重症肺心病心力衰竭的效果

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Abstract ObjectiveTo explore the effect of Recombinant Human Brain Natriuretic Peptide combined with Low Molecular Weight Heparin Calcium in the treatment of severe pulmonary heart disease with heart failure.MethodsClinical data of 88 cases with severe pulmonary heart disease with heart failure treated in Panyu District Central Hospital from June 2015 to June 2016 were analyzed.Patients were divided into the control group(Nitroglycerin treatment,n= 44)and the combined group (Recombinant Human Brain Natriuretic Peptide combined with Low Molecular Weight Heparin Calcium treatment,n=44)according to different treatment methods.Left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVDd),brain natriuretic peptide(BNP)and C reactive protein(CRP),serum creatinine (SCr)before and after treatment in two groups were observed,and the total effective rate in two patients were observed.ResultsAfter treatment,LVEF [(38.1±3.2)%and (42.7±3.5)%]of the control group and combined group were higher than before treatment，LVDd[(61.2±3.1)mm and(55.2±3.4)mm],BNP[(1687.5±109.8)ng/L and(1050.4±99.8)ng/L], CRP[(17.8±4.0)mg/L and(13.2±3.7)mg/L],SCr[(122.9±29.8)mmol/L and(104.1±26.2)mmol/L]were lower than before treatment;LVEF of combined group after treatment was higher than that of control group,LVDd,BNP,CRP,SCr were lower than those of control group;the total effective ratein the combined group(97.7%)was higher than that of the control group (75.0%),and the differences were statistical significance (P<0.05).ConclusionRecombinant Human Brain Natriuretic Peptide combined with Low Molecular Weight Heparin Calcium in the treatment of severe pulmonary heart disease with heart failure can improve obviously the cardiac function,and the curative effect is good.It is worthy of clinical promotion and application.

Key words： Recombinant Human Brain Natriuretic Peptide Low Molecular Weight Heparin Calcium Severe pulmonary heart disease Heart failure

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	WEN Yong-hong

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WEN Yong-hong. Effect of Recombinant Human Brain Natriuretic Peptide combined with Low Molecular Weight Heparin Calcium in the treatment of severe pulmonary heart disease with heart failure[J]. 中国当代医药, 2017, 24(11): 38-40转44.

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