结核分枝杆菌T细胞斑点试验、肺泡灌洗液T细胞亚群检测在肺结节病和肺结核鉴别诊断作用

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Abstract Objective To study the differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid. Methods A total of 60 patients with pulmonary diseases admitted to the Department of Tuberculosis, Jiangxi Chest Hospital from March 2019 to March 2020 were selected as the research objects. According to the different types of disease, they were divided into observation group (pulmonary sarcoidosis, 30 cases) and control group (pulmonary tuberculosis, 30 cases). Mycobacterium tuberculosis T cell spot test and alveolar lavage fluid T-cell subsets were performed to compare the positive rate and levels of CD4+/CD8+, CD8+,CD4+ and CD3+ between the two groups. Results In the mycobacterium tuberculosis T-cell spot test in the observation group, there were 2 tuberculosis infection T-cell spot test positive patients, the positive rate was 6.67%. In the mycobacterium tuberculosis T-cell spot test of the control group, 11 patients with tuberculosis infection t-cell spot test were positive, the positive rate was 36.67%. The positive rate of mycobacterium tuberculosis T-cell spot test in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). CD4+/CD8+ (1.31±0.07) and CD8+ ([27.41±6.71] %) in observation group were lower than those in control group ([2.91±0.15]and [32.11±7.61] %), and the differences were statistically significant (P＜0.05). CD4+([63.51±7.26] %) and CD3+([88.79±5.31] %) were higher than those in the control group ([41.27±3.1], [76.19±6.21] %), and the differences were statistically significant (P＜0.05). Conclusion In the diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis, mycobacterium tuberculosis T-cell spot test and alveolar lavage fluid T-cell subgroup detection can be used to identify these diseases effectively.

Key words： Mycobacterium tuberculosis T cell spot test T cell subsets in alveolar lavage fluid Pulmonary sarcoidosis Pulmonary tuberculosis

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	DENG Qun
	LIU Jian-feng
	YAO Jia-hui-zi
	HUANG Jian

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DENG Qun,LIU Jian-feng,YAO Jia-hui-zi, et al. Differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid[J]. 中国当代医药, 2021, 28(30): 154-156.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I30/154

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