|
|
Differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid |
DENG Qun LIU Jian-feng YAO Jia-hui-zi HUANG Jian▲ |
Department of Tuberculosis, Jiangxi Chest Hospital, Jiangxi Province |
|
|
Abstract Objective To study the differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid. Methods A total of 60 patients with pulmonary diseases admitted to the Department of Tuberculosis, Jiangxi Chest Hospital from March 2019 to March 2020 were selected as the research objects. According to the different types of disease, they were divided into observation group (pulmonary sarcoidosis, 30 cases) and control group (pulmonary tuberculosis, 30 cases). Mycobacterium tuberculosis T cell spot test and alveolar lavage fluid T-cell subsets were performed to compare the positive rate and levels of CD4+/CD8+, CD8+,CD4+ and CD3+ between the two groups. Results In the mycobacterium tuberculosis T-cell spot test in the observation group, there were 2 tuberculosis infection T-cell spot test positive patients, the positive rate was 6.67%. In the mycobacterium tuberculosis T-cell spot test of the control group, 11 patients with tuberculosis infection t-cell spot test were positive, the positive rate was 36.67%. The positive rate of mycobacterium tuberculosis T-cell spot test in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). CD4+/CD8+ (1.31±0.07) and CD8+ ([27.41±6.71] %) in observation group were lower than those in control group ([2.91±0.15]and [32.11±7.61] %), and the differences were statistically significant (P<0.05). CD4+([63.51±7.26] %) and CD3+([88.79±5.31] %) were higher than those in the control group ([41.27±3.1], [76.19±6.21] %), and the differences were statistically significant (P<0.05). Conclusion In the diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis, mycobacterium tuberculosis T-cell spot test and alveolar lavage fluid T-cell subgroup detection can be used to identify these diseases effectively.
|
|
|
|
|
[1] |
孙海柏,张丽霞,王潇,等.T-SPOT 及肺泡灌洗液T 细胞亚群检测在肺结核及肺结节病鉴别诊断中的意义[J].国际检验医学杂志,2016,37(17):2465-2467.
|
[2] |
庞凡,仲燕,刘雅.肺结节病患者支气管肺泡灌洗液及外周血中T 淋巴细胞亚群水平检测的意义[J].检验医学与临床,2019,16(20):3013-3015.
|
[3] |
王能勇.流式细胞术检测肺泡灌洗液T 淋巴细胞亚群的诊断价值[J].中国保健营养,2020,30(31):24-25.
|
[4] |
洪燕燕,杨芝红.流式细胞术检测肺泡灌洗液T 淋巴细胞亚群的诊断价值[J].检验医学与临床,2017,14(14):2051-2053.
|
[6] |
石学萍,王晶,王鑫,等.结核分枝杆菌感染T 细胞斑点试验在疑诊肺结核患者中的临床应用[J].解放军医学杂志,2017,42(11):996-1000.
|
[5] |
Shima H,Nishitani M,Tashiro M,et al.Pulmonary sarcoidosis as a cause of intermittent fever of unknown orf unknown origin in a hemodin a hemover of unknown origin in a hemodialydias patient wiver of unknown origin in a hemodialyth renal cell carce report anver of unknown origin in a hemodialyd literature review[J].Hemodial Int,2019,4(1):21-23.
|
[7] |
林芳,贾楠,于刚刚,等.支气管肺泡灌洗液细胞分类及CD4+/CD8+对间质性肺疾病的诊断价值[J].临床肺科杂志,2019,24(8):1359-1362.
|
[8] |
Aravena C,Almeida FA,Culver DA,et al.The utility of endobronchial ultrasound-transbronchial needle aspiration in patients with suspected extra-pulmonary sarcoidosis without thoracic lymphadenopathy[J].Respir Med,2020,3(2):17-21.
|
[9] |
韩利梅,穆清爽,努尔阿米娜·铁力瓦尔迪,等.结核分枝杆菌T 细胞斑点试验(T-SPOT.TB)技术在结核性胸膜炎诊断中的诊断价值[J].湖南师范大学学报(医学版),2018,15(2):32-35.
|
10 |
]吴佳玲,罗丹,傅满姣,等.结核感染T 细胞斑点试验、腺苷脱氨酶及结核杆菌抗体对结核性胸膜炎的诊断价值分析[J].实用心脑肺血管病杂志,2016,24(5):71-74.
|
[11] |
李强,陈红梅,吕子征,等.分枝杆菌培养阳性外周血结核感染T 细胞斑点试验阴性病例的临床特征分析[J].中国临床医生杂志,2020,48(1):72-74.
|
[12] |
黄银娜.结核感染T 细胞斑点试验、结核分枝杆菌抗体检查应用于肺结核患者诊断中的价值对比[J].中国医学创新,2020,17(35):133-136.
|
[13] |
张玺,杨国儒,于雯雯.结核感染T 细胞斑点试验在支气管扩张症合并非结核分枝杆菌肺病诊断中的预测价值[J].潍坊医学院学报,2017,39(2):90-92.
|
[14] |
杜晓,马显军,苏日娜.结核分枝杆菌T 细胞斑点试验技术在结核性胸膜炎诊断及鉴别诊断中的价值分析[J].中国继续医学教育,2016,8(33):51-53.
|
[15] |
姚雨濛,潘珏,高晓东,等.T 细胞斑点试验对活动性结核与非结核分枝杆菌感染的鉴别诊断价值[J].中华医院感染学杂志,2017,27(12):2683-2685,2690.
|
[16] |
薛永新,杜焰家,张伟强.T 细胞斑点试验联合腺苷脱氨酶在结核性胸膜炎诊断中的应用价值[J].中国当代医药,2019,26(12):79-81.
|
[17] |
李芹,张静.肺结节病患者T 淋巴细胞亚群检测的诊断价值[J].宁夏医学杂志,2018,40(10):944-945.
|
|
|
|