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| Effect of Sevoflurane intravenous inhalation combined anesthesia on the immune function and hemodynamics of patients with cervical cancer |
| GE Yu-ting |
| Department of Anesthesiology,Maternal and Child Health Hospital of Dalian Jinpu New District,Liaoning Province,Dalian 116100,China |
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Abstract Objective To analyze the effect of Sevoflurane intravenous inhalation combined anesthesia on the immune function and hemodynamics of patients with cervical cancer.Methods A total of 54 patients with cervical cancer admitted to Maternal and Child Health Hospital of Dalian Jinpu New District from April 2017 to April 2020 were selected as the research objects.According to the random number table method,they were divided into a control group(27 cases)and an experimental group (27 cases).Patients in the control group were treated with Propofol continuous anesthesia,and patients in the experimental group were treated with Sevoflurane intravenous inhalation combined anesthesia.The perioperative immune function levels,serum nerve growth factor (NGF),brain-derived neurotrophic factor (BDNF) levels and hemodynamic levels in different time periods were compared between the two groups of patients.Results The levels of CD4+CD25+T and CD4+OX40+T in the two groups at 48 hours after operation were lower than those before operation,the differences were statistically significant(P＜0.05); and the levels of CD4+CD25+T and CD4+OX40+T in the experimental group at 48 hours after operation were lower than those in the control group,the differences were statistically significant (P＜0.05).The levels of NGF and BDNF at 48 hours after operation were lower than those before operation,the differences were statistically significant (P＜0.05); and the levels of NGF and BDNF in the experimental group at 48 hours after operation were higher than those in the control group,the differences were statistically significant (P＜0.05).There were no significant differences in heart rate (HR),mean arterial pressure (MAP),blood oxygen saturation(SpO2) between the two groups at 5 minutes before anesthesia (P＞0.05); at 5 minutes after anesthesia and the beginning of the operation,the HR and MAP of the experimental group were lower than those of the control group,and SpO2 was higher than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Sevoflurane intravenous inhalation combined anesthesia is used for the surgical treatment of cervical cancer,it helps to reduce immune response and maintain hemodynamic stability.
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| [1] |
陈萍，王东伟，刘曼，等.丙泊酚和七氟醚对宫颈癌手术围术期免疫功能的影响[J].黑龙江医药科学，2019，42（6）：16-17.
|
| [2] |
陈锴，张兆伟，秦妮娜.丙泊酚和七氟醚对行腹腔镜子宫切除术宫颈癌患者围手术期免疫反应的影响[J].实用癌症杂志，2018，33（5）：769-772.
|
| [3] |
孙立峰.七氟醚复合瑞芬太尼麻醉对宫颈癌术后应激反应的影响研究[J].中国保健营养，2019，29（31）：87-88.
|
| [4] |
范涛，陈婷婷，洪毅.七氟醚静吸复合麻醉对腹腔镜下行宫颈癌根治术患者术后早期认知功能及血清BDNF、NGF 的影响[J].中国医师杂志，2018，20（2）：253-255.
|
| [5] |
Liu S，Gu X，Zhu L，et al.Effects of Propofol and Sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer[J].Medicine，2016，95（49）：5479.
|
| [6] |
王志刚，卫晓娜，侯俊德，等.七氟烷与丙泊酚对腹腔镜下宫颈癌根治术患者 围术期免疫功能的影响[J].现代中西医结合杂志，2019，28（17）：1911-1914.
|
| [7] |
Lim JA，Oh CS，Yoon TG，et al.The effect of Propofol and Sevoflurane on cancer cell，natural killer cell，and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery：an in vitro analysis[J].Bmc Cancer，2018，18（1）：159.
|
| [8] |
杨海峰，瞿玉莲.舒芬太尼与丙泊酚静脉复合麻醉对宫颈癌患者免疫功能的影响[J].中国妇幼健康研究，2019，30（3）：320-325.
|
| [9] |
曾和清，易理生，肖文军.持续静注右美托咪定对腹腔镜下宫颈癌根治术患者全麻恢复期的影响[J].实用肿瘤学杂志，2016，30（2）：135-139.
|
| [10] |
沈亚建，方军，周惠丹，等.七氟醚和丙泊酚对行腹腔镜宫颈癌根治术患者炎症因子及应激反应的影响[J].中华全科医学，2017，15（1）：66-68.
|
| [11] |
刘炯峰，李敬业，赖斐然.七氟醚静吸复合麻醉对腹腔镜下行宫颈癌根治术患者术后早期认知功能的影响[J].齐齐哈尔医学院学报，2019，40（1）：42-43.
|
| [12] |
刘松涛，周海，周美艳，等.丙泊酚和七氟醚对子宫颈癌患者行腹腔镜根治性子宫切除术围术期免疫功能的影响[J].徐州医学院学报，2017，37（1）：5-9.
|
| [13] |
武建，张荣，王乐，等.CYP2B6 基因多态性对宫颈癌患者应用右美托咪定麻醉效果的影响[J].广东医学，2019，40（16）：2339-2344.
|
| [14] |
常政，杨世忠.全身麻醉联合硬膜外麻醉与单纯全身麻醉在宫颈癌手术中的应用效果分析[J].中国妇幼保健，2020，35（11）：1973-1975.
|
| [15] |
孙杨.七氟醚静吸复合麻醉对腹腔镜下宫颈癌根治术患者炎症反应及麻醉效果的影响[J].中国当代医药，2019，26（9）：101-104.
|
|
|
|
