联合血液净化治疗在重症急性胰腺炎患者中的应用

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Abstract Objective To investigate the application of combined blood purification therapy (CBP) in patients with severe acute pancreatitis (SAP). Methods From February 2019 to February 2020, 76 patients with severe acute pancreatitis treated in the Intensive Care Unit (ICU), People′s Hospital of Xiangzhou District were selected as the research objects. They were divided into the reference group and the test group according to the random number table method, with 38 cases in each group. The patients in the reference group were treated with oxygen therapy, fasting water, nutritional support,anti-shock,anti-inflammatory,anti-pancreatic enzyme and so on.The test group was treated with CBP(hemofiltration+hemoperfusion) on the basis of routine comprehensive treatment. The levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), mortality, blood amylase recovery time, ICU stay and total hospital stay in the two groups were compared. Results Before treatment, there were no statistically significant differences in the levels of CRP, IL-6 and TNF-α between the two groups (P＞0.05). After treatment, the levels of CRP, IL-6 and TNF-α in the groups were lower than those before treatment, the differences were statistically significant (P＜0.05), and the levels of CRP, IL-6 and TNF-α in test group were lower than those in the reference group, the differences were statistically significant (P＜0.05). The mortality of the test group was lower than that of the reference group, and the recovery time, ICU residence time and total hospitalization time of the test group were shorter than those of the reference group,and the differences were statistically significant (P＜0.05). Conclusion CBP adjuvant routine treatment in patients with severe acute pancreatitis can effectively reduce the level of inflammatory factors, improve mortality and shorten the recovery time.

Key words： Critical acute pancreatitis Inflammatory factors C-reactive protein Interleukin-6 Tumor necrosis factor-α Combined blood purification therapy

Received: 20 October 2020

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