|
|
|
| Study on the predictive value of IL-6 and TNF-α in the severity of druginduced liver injury |
| TAN Li-juan1 XU Pei-yan1 LI li |
1.Department of Infectious Diseases, Guangzhou Huadu District People′s Hospital, Guangdong Province, Guangzhou 510800, China;
2.Department of Cardiology, Guangzhou Huadu District People′s Hospital, Guangdong Province,Guangzhou 510800, China |
|
|
|
|
Abstract Objective To explore the clinical value of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)levels in the prediction of drug-induced liver injury severity.Methods A total of 61 patients with drug-induced liver injury in Guangzhou Huadu District People′s Hospital from May 2018 to December 2019 were collected as research subjects.According to the severity of liver injury, the patients were divided into mild liver injury group (n=30), moderate liver injury group (n=24) and severe liver injury group (n=7).Another 35 cases of healthy people in the same period were selected as the normal control group.The serum levels of IL-6 and TNF-α were detected by double antibody sandwich enzyme-linked immunosorbent assay.Results Before treatment, the levels of serum IL-6 and TNF- α in mild liver injury group, moderate liver injury group and severe liver injury group were higher than those in the normal control group, the differences were statistically significant(P＜0.05).With the aggravation of liver injury, the levels of serum IL-6 and TNF-α increased gradually, the differences among the groups were statistically significant (P＜0.05).After 3 days of treatment, the levels of serum IL-6 and TNF-α in mild liver injury group, moderate liver injury group and severe liver injury group were lower than those before treatment, the differences were statistically significant(P＜0.05).After 2 weeks of treatment, the levels of IL-6, TNF-α and glutamic oxalacetic transamindse (AST) in the effective group were lower than those in the ineffective group, the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that the levels of IL-6 and TNF-α in patients with drug-induced liver injury were positively correlated with AST and alanine transaminase (ALT) before treatment (P＜0.05).Conclusion Serum IL-6 and TNF-α can be used to predict the severity and prognosis of drug-induced liver injury,and have high clinical value.
|
|
|
|
|
|
| [1] |
李亚飞，闫华楠，韩少静，等.老年急性药物性肝损伤临床特征及预后影响因素分析[J].肝脏，2020，25（3）：319-322.
|
| [2] |
杨雪松，孟繁坤，张嫄.声学结构定量技术应用于药物性肝损伤的诊断价值[J].临床和实验医学杂志，2017，16（24）：2481-2484.
|
| [3] |
杨雪，涂荣芳，杨晋辉.药物性肝损伤的研究进展[J].临床肝胆病杂志，2020，36（3）：509-513.
|
| [4] |
杨松，郭建琼，严晓峰.抗结核药物性肝损伤发生机制的研究进展[J].中华结核和呼吸杂志，2019，42（5）：378-381.
|
| [5] |
曾怡，潘青波，沈妍希，等.中和白细胞介素-6 减轻小鼠急性肝损伤[J].中华肝脏病杂志，2020，28（6）：509-514.
|
| [6] |
刘萍.TNF-α 在肝衰竭疾病中作用的研究进展[J].湖南中医杂志，2016，32（9）：188-190.
|
| [7] |
中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志，2015，31（11）：1752-1769.
|
| [8] |
王准，龚天斌.3 种常用改善肝功能药物治疗药物性肝损伤的效果比较[J].临床肝胆病杂志，2016，32（4）：761-763.
|
| [9] |
王静，马园园，刘成海，等.基于文献的药物性肝损伤流行病学分析[J].中西医结合肝病杂志，2019，29（5）：452-455，458.
|
| [10] |
王全华，付辛芳，虢艳宁，等.药物性肝损伤患者用药情况及临床特征分析[J].检验医学与临床，2019，16（24）：3623-3626.
|
| [11] |
李银玲，翁丽媚，吴思思，等.药物性肝损伤时肾生物化学指标的改变及其临床意义[J].中华肝脏病杂志，2019，27（2）：143-145.
|
| [12] |
侯俊兴，严粉琴，于乐成.药物性肝损伤合并肝外药物不良反应的发生机制及诊疗现状[J].临床肝胆病杂志，2020，36（3）：497-500.
|
| [13] |
马雅斌，李语玲，张津.熊去氧胆酸联合S-腺苷蛋氨酸对药物性肝损伤患者肝功能、Nrf2 抗氧化、炎症反应的影响[J].临床和实验医学杂志，2018，17（24）：2606-2610.
|
| [14] |
李虎，陈立，张欣欣.药物性肝损伤实验诊断研究进展[J].中华肝脏病杂志，2020，28（6）：536-539.
|
| [15] |
余曦，杨蓉蓉.药物性肝损伤384 例临床分析[J].中华全科医师杂志，2020，19（4）：340-344.
|
| [16] |
杨忠毅，曹江.不同预防性保肝用药方案对急性髓系白血病首次化疗后肝损伤的影响 [J].中国药物警戒，2019，16（4）：203-207.
|
| [17] |
张一杨，李莹淑，李金凤，等.SIRT1 及相关因子在抗结核药物致人肝细胞损伤中的作用[J].重庆医学，2018，47（31）：3965-3972.
|
| [18] |
孟慧杰，杨雪迎，覃红娟，等.炎症细胞因子对抗结核性药物肝损伤的预测作用[J].实用医学杂志，2019，35（2）：238-241.
|
|
|
|
