同型半胱氨酸、叶酸与维生素B12水平的相关性分析及不良妊娠结局的危险因素考察

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Abstract Objective To investigate the correlation between homocysteine, folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome.Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group, and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group.The results of serum test were observed and compared, and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed, and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis.Results The homocysteine in the study group was (11.20±2.85) μmol/L, which was higher than that in the control group (9.35±1.02)μmol/L, and the difference was statistically significant (P＜0.05).The folic acid index in the study group was (6.10±1.55) ng/ml, lower than that in the control group (6.95±1.68) ng/ml, and the difference was statistically significant (P＜0.05).The vitamin B12 index in the study group was (78.30±28.75) pg/ml, which was lower than that in the control group (98.35 ±45.50) pg/ml, and the difference was statistically significant (P＜0.05).The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088, P=0.000).The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109, P=0.001).Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine, the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541, OR=1.708, 95%CI=0.039-1.895, P＜0.05; β=0.003, OR=1.001, 95%CI=0.001-1.109, P＜0.05; β=0.004, OR=1.002, 95%CI=0.001-1.010, P＜0.05).Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine, the decrease of vitamin B12 level and the decrease of folic acid.Therefore, combined with the situation of pregnant women, the monitoring of homocysteinemia, vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome.

Key words： Homocysteine Folic acid 12 level')" href="#">Vitamin B12 level Adverse pregnancy outcome Correlation

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	Articles by authors
	LI Chao-hui
	HU Ya
	OU Min-yi
	HUANG Wei-jian
	CAO Zi-jie

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LI Chao-hui,HU Ya,OU Min-yi, et al. Analysis of the correlation between homocysteine, folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome[J]. 中国当代医药, 2020, 27(3): 165-167.

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