Objective To explore the clinical effect of radiofrequency ablation combined with targeted therapy under CT on renal cancer.Methods A total of 79 patients with renal cancer treated in Benxi Central Hospital from February 2018 to April 2019 were selected as the research objects, and randomly divided into the control group (n=39) and the observation group (n=40) according to the double-blind method.The control group was treated with targeted therapy,and the observation group was treated with radiofrequency ablation + targeted therapy under CT.The clinical efficacy and tumor marker levels of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).There were no significant differences between the two groups in the levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) before treatment (P>0.05);the levels of CEA and CA125 after treatment in the two groups were lower than those before treatment, and the levels of CEA and CA125 in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusions Radiofrequency ablation combined with targeted therapy for renal cancer using CT has significant curative effect and can effectively reduce tumor marker levels.