牛黄对治疗脑梗死的调控网络和潜在机制研究

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Abstract Objective To predicit the potential target of Bezoar in the treatment of cerebral infarction via network pharmacology and to explore its regulatory network and mechanism of action. Methods The main active components of Bezoar were were obtained through traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) database and literature mining, and the target of the active ingredients of Bezoar was predicted and screened using the human gene database GeneCards. String database and Cytoscape 3.7.1 software were used to draw protein interaction (PPI) network, and gene ontology (GO) analysis of potential genes was performed with the application of DAVID6.8 database. Results A total of 5 active ingredients of Bezoar were obtained by screening, involving 3 targets.GO analysis results showed that the biological process of Bezoar in the treatment of cerebral infarction mainly involved steroid hormone receptor activity, nuclear receptor activity, transcription factor activity, steroid binding, vitamin D receptor binding, nuclear receptor binding, chromatin DNA binding, and ATPase binding, etc. Conclusion The treatment of cerebral infarction by Bezoar is a complex process with multiple components and multiple targets, mainly by regulating the three targets of NR3C2, PGR and RXRA, involving nuclear receptor activity, transcription factor activity,steroid binding, vitamin D receptor binding, chromatin DNA binding, ATPase binding and other biological processes to play a role in intervening cerebral infarction.

Key words： Network pharmacology Bezoar Cerebral infarction Potential mechanism

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	Articles by authors
	LIANG Yu-hua
	HE Hua-hua
	DENG Tai-ping

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LIANG Yu-hua,HE Hua-hua,DENG Tai-ping. Study on the regulatory network and potential mechanism of Bezoar in the treatment of cerebral infarction[J]. 中国当代医药, 2020, 27(19): 8-11.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I19/8

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