术前肠道去污预防ERCP术后急性胰腺炎的前瞻性随机对照研究

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Abstract Objective To investigate the curative effect of preoperative intestinal decontamination on preventing acute pancreatitis and hyperamylasemia in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).Methods Altogether 110 patients who underwent ERCP in our hospital from January 2019 to January 2020 were selected as the study subjects. According to the random number table method, the subjects were divided into the experimental group and the control group, 55 cases in each group. ERCP was performed in both groups. The experimental group was given Compound Polyethylene Glycol Electrolyte Powder 2000 ml orally at 7 pm before operation, and the control group was given clear water 2000 ml orally.The levels of WBC,ALT and TBil were measured before and 24 hours after operation.The incidence of acute pancreatitis and hyperamylasemia was recorded between the two groups.The defecation time, abdominal pain score, hospitalization time and medical expenses were compared between the two groups.The prognosis during hospitalization and other complications were observed between the two groups. Results The levels of WBC, ALT and TBil at 24 hours after operation in the two groups were lower than those before operation, and the differences were statistically significant (P＜0.05). The levels of WBC, ALT and TBil 24 hours after operation in the experimental group were lower than those in the control group, with significant differences (P＜0.05). The incidence of acute pancreatitis and hyperamylasemia after ERCP in the experimental group was lower than that in the control group,with significant difference (P＜0.05). Postoperative defecation time and hospitalization time of the experimental group were shorter than those of the control group, abdominal pain score was lower than that of the control group, and medical expense was lower than that of the control group, with significant differences (P＜0.05). The cure discharge rate of the experimental group was higher than that of the control group, and the mortality of the experimental group was lower than that of the control group, and the differences were statistically significant (P＜0.05). The incidence of infection and bleeding after operation in the experimental group was lower than that in the control group, with significant difference(P＜0.05). Conclusion Preoperative intestinal decontamination can reduce the incidence of acute pancreatitis after ERCP, alleviate postoperative abdominal pain and other discomforts, improve the prognosis of patients and reduce medical costs, which is worthy of clinical application.

Key words： Preoperative intestinal decontamination Acute pancreatitis Endoscopic retrograde cholangiopancreatography Hyperamylasemia

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	Articles by authors
	SHU Hong-chun
	LIAN Huo-jun
	ZHUGE Qun
	ZHOU Wei-ping
	ZHENG Mei-hong
	DENG Hui-qiu

Cite this article:

SHU Hong-chun,LIAN Huo-jun,ZHUGE Qun, et al. Prospective randomized controlled study of preoperative intestinal decontamination in the prevention of acute pancreatitis after ERCP[J]. 中国当代医药, 2020, 27(19): 42-45.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I19/42

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