羟考酮与布托啡诺预防舒芬太尼诱导引起咳嗽的效果比较

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Abstract Objective To investigate the effect of Oxycodone and Butorphanol in preventing Sufentanil-induced cough.Methods A total of 120 patients (aged 18-60 years，American Association of Anesthesiologists ［ASA］ Ⅰ-Ⅱ) undergoing elective surgery for general anesthesia intubation in our hospital from September 2018 to October 2019 were selected as the research subjects. They were divided into group O，group B and group S according to the random number table method，40 cases in each group. Patients in group O received intravenous injection of 0.05 mg/kg Oxycodone，patients in group B received intravenous injection of 0.01 mg/kg Butorphanol，and patients in group S received intravenous equivalent volume of 0.9% normal saline. Sufentanil 0.4 μg/kg was injected 30 seconds later and administrated within 5 seconds. Other anesthesia drugs were given 1 minute later for induction and endotracheal intubation. The severity and incidence of cough during anesthesia induction，as well as the average arterial pressure (MAP) and heart rate (HR) before anesthesia induction (T0)，before the injection of Sufentanil (T1)，2 minutes after endotracheal intubation (T2) were observed and recorded. Results The total incidence rate of cough in group S was 35.0% (14/40，mild 4 cases，moderate 7 cases，and severe 3 cases)，group O was 10.0% (4/40，mild 3 cases，moderate 1 case)，and group B was 12.5% (5/40，mild 5 cases). The total incidence rate and severity of cough of patients in group O and B were lower than those in group S，and the differences were statistically significant (P＜0.05). There were no significant differences in the total incidence rate and severity of cough between group O and group B (P＞0.05). At T0，T1 and T2，there were no significant differences in MAP and HR among the three groups (P＞0.05). Conclusion Oxycodone at 0.05 mg/kg and Butorphanol at 0.01 mg/kg can safely and effectively prevent Sufentanil-induced cough with similar effect.

Key words： Oxycodone Butorphanol Sufentanil General anesthesia Cough

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