肝脏缺血再灌注立早基因表达的研究进展

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Abstract Hepatic ischemia reperfusion injury is a common and important complications in clinical hepatobiliary surgery.During the process of ischemia and reperfusion early response protein-1, c-Jun, c-Fos of immediate early genes expression was up-regulated, regulating hepatic tissue inflammatory response, resulting in serious hepatic function abnormalities and organ dysfunction.Those immediate early genes also regulate hepatic tissue regeneration and reconstruction in convalescent stage, playing an important role in hepatic energy metabolism, which has an important impact on the survival and prognosis of patients.Immediate early genes are a kind of genes which can be induced quickly and briefly after stimulation, and their activation do not require synthesis of any new proteins.So far, more than 100 kinds of immediate early genes have been found in cells.In-depth understanding of the expression and regulation of immediate early genes in hepatic ischemia-reperfusion may provide a new direction for ameliorating hepatic ischemia reperfusion injury and hepatic recovery after injury.This paper reviews the research progress of early gene expression of liver ischemia-reperfusion.

Key words： Hepatic ischemia reperfusion Early growth response-1 c-Fos c-Jun

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	DENG Xiao-yu
	MA Li

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DENG Xiao-yu,MA Li. Research progress on the expression of immediate early gene in hepatic ischemia reperfusion[J]. 中国当代医药, 2020, 27(12): 38-41.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I12/38

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