不同剂量泼尼松龙联合氯米芬治疗多囊卵巢综合征高雄激素不孕的效果比较

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Abstract [Abstract]Objective To compare the effect of different dosage of Prednisolone combined with Clomiphene in the treatment of hyperandrogenic infertility in patients with polycystic ovary syndrome (PCOS).Methods A total of 160 PCOS patients with hyperandrogenic infertility who visited gynecology clinic in our hospital from January 2017 to April 2018 were selected as the study subjects,and divided into group A,group B,group C and group D by random number table method,with 40 cases in each group.Group D as the control group was treated with Clomiphene 50 mg/d×5 d,while group A,group B and group C were treated with Prednisolone Tablets 20 mg/d,15 mg/d and 10 mg/d respectively.They were all treated for 3 days.After treatment,the reproductive hormone levels of testosterone(T),luteinizing hormone(LH),estradiol(E2)and follicle stimulating hormone(FSH),the number and diameter of mature follicles,the number and diameter of dominant follicles,ovulation rate and pregnancy rate were compared.Results The T level of group C was significantly lower than that of group A,group B and group D,and the levels of LH,E2and FSH were significantly higher than those of group A,group B and group D (P<0.05).The diameter of mature follicles in group C was significantly longer than that in group A,group B and group D (P<0.05).There was no significant difference in the number of mature follicles,the number of dominant follicles and the thickness of endometrium among group A,group B,group C and group D (P>0.05).The ovulation rate in group A,group B and group C was significantly higher than that in group D (P<0.05).There was no significant difference in pregnancy rate among group A,group B,group C and group D (P>0.05).Conclusion The optimal dose of Prednisolone combined with Clomiphene in the treatment of PCOS hyperandrogenic infertility is 10 mg/d,which can effectively reduce the level of androgens in vivo,improve the level of estrogen,and has a significant effect on promoting ovulation and pregnancy.

Key words： Prednisolone Clomiphene Polycystic ovary syndrome Hyperandrogenic

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