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| Clinical effect of Norepinephrine combined with Dobutamine in the treatment of cardiogenic shock |
| SU Hua-feng |
| Department of Critical Care Medicine, Shenzhen Hospital, University of Chinese Academy of Sciences, Guangdong Province, Shenzhen 581110, China |
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Abstract Objective To investigate the clinical effect of Norepinephrine combined with Dobutamine in the treatment of cardiogenic shock.Methods The 68 patients with cardiogenic shock admitted to our hospital from August 2016 to August 2018 were selected as subjects and were divided into the single group (34 cases) and combined group (34 cases) according to the method of random grouping.The single group used Dobutamine method.The combined group used Dobutamine combined Norepinephrine method.The results of treatment, left ventricular ejection fraction (LVEF), systolic blood pressure, diastolic blood pressure, brain natriuretic peptide (BNP), creatinine and urinary volume were compared with the incidence of adverse reactions.Results The total effective rate of treatment in the combined group was 94.1%, which was higher than 73.5% in the single group, and the difference was statistically significant (P＜0.05).There was no significant difference in LVEF, systolic blood pressure, diastolic blood pressure, creatinine and urine volume between the two groups before treatment (P＞0.05).After treatment, the LVEF, systolic blood pressure, diastolic blood pressure and urine volume of the two groups were higher than that before treatment, while BNP and creatinine were lower than that before treatment, and the differences were statistically significant (P＜0.05).After treatment, the LVEF, systolic blood pressure, BNP, creatinine and urine volume of patients in the combined group were compared with those in the single group, and the differences were not statistically significant (P＞0.05).After treatment, the diastolic blood pressure of the combined group was higher than that of the combined group, and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the combined group (14.76%) was lower than that in the single group(41.2%), and the difference was statistically significant (P＜0.05).Conclusion The effect of Norepinephrine combined with Dobutamine in the treatment of cardiogenic shock is ideal, and it has high safety and is worth promoting.
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