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| Effect of 3%Hypertonic Saline atomization inhalation combined with Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children |
| YU Dong-hui1 LIU Ying-hui1 LI Yong-hong2 YU Li-ying1 |
| 1.Second Department of Pediatrics,the People′s Hospital in Langfang City,Hebei Province,Langfang 065000,China;2.Department of Pediatrics,the Third People′s Hospital in Langfang City,Hebei Province,Langfang 065000,China |
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Abstract Objective To observe the therapeutic effect of 3%Hypertonic Saline atomization inhalation combined with Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children.Methods From November 2013 to November 2016,451 children with bronchiolitis,aged from 1 month to 2 years,who were admitted to the department of pediatrics in the People′s Hospital in Langfang City were selected as the study subjects.The subjects were randomly divided into the control group(n=227)and the treatment group(n=224)by random number table method.Two groups of patients were treated by conventional methods.In the control group,children were treated with Budesonide combined with Salbutamol inhalation,and the treatment group were treated on the basis of the control group plus 3%Hypertonic Saline.The clinical efficacy,hypoxia symptom score,duration of symptoms,hospital stay and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the treatment group(86.2%)was higher than that in the control group(80.6%),and the difference was statistically significant(P＜0.05).After treatment 1,3,5 days,the scores of hypoxia symptom in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The duration of coughing continued,the wheezing continued,the recovery time of blood gas and the time of sound disappeared in the treatment group shorter than those in the control group,and the differences were statistically significant(P＜0.05).The average length of hospital stays in the treatment group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The 3%Hypertonic Saline inhalation combined Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children is remarkable.This treatment method has certain clinical application value for the treatment of children with bronchiolitis.
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| [1] |
Mansbach JM，Piedra PA，Teach SJ，et al.Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis[J].Arch Pediatr Adolesc Med，2012，166（8）：700-706.
|
| [2] |
司马丽，张明亮，肖蓉，等.不同浓度NaCl溶液联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效分析[J].中国当代医药，2012，19（30）：73-74.
|
| [3] |
刘青，李虎，万俊，等.高渗盐水雾化吸入治疗毛细支气管炎的疗效观察[J]临床肺科杂志，2017，22（4）：705-707.
|
| [4] |
彭万胜，陈信，李冬娥.雾化吸入高渗盐水治疗婴幼儿毛细支气管炎疗效和安全性的Meta分析[J].中国循证儿科杂志，2011，6（5）：358-362.
|
| [5] |
陆娇，顾珺，马卫宁，等.雾化吸入不同浓度高渗盐水治疗中重度毛细支气管炎的疗效和安全性研究[J]中国小儿急救医学，2017，24（6）：425-429.
|
| [6] |
陈国松.雾化吸入高渗盐水联合布地奈德治疗毛细支气管炎的疗效[J].吉林医学，2015，36（2）：245.
|
| [7] |
郭佳群，杨敏，郭梓伟.雾化吸入高渗盐水联合布地奈德治疗毛细支气管炎的疗效[J].广东医学，2012，33（4）：542-543.
|
| [8] |
Oakley E，Bata S，Rengasamy S，et al.Nasogastric hydration in infants with bronchiolitis less than 2 months of age[J].J Pediatr，2016，（178）：241-245.
|
| [9] |
戴本启，陈捷，罗玉婷，等.高渗盐水联合布地奈德雾化吸入治疗小儿毛细支气管炎的效果观察[J].中国当代医药，2017，24（35）：122-124.
|
| [10] |
隋登宇.单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎的临床研究[J].现代药物与临床，2017，32（2）：241-244.
|
| [11] |
王晓斌.雾化吸入高渗盐水联合布地奈德、沙丁胺醇治疗婴幼儿毛细支气管炎疗效观察[J].实用药物与临床，2014，17（2）：186-188.
|
| [12] |
欧有平.孟鲁斯特钠联合布地奈德和复方异丙托溴铵治疗婴幼儿毛细支气管炎的疗效观察[J].现代药物与临床，2016，31（3）：375-378.
|
| [13] |
范娟，李茂军，吴青，等.毛细支气管炎的临床管理——美国儿科学会临床实践指南简介[J].中华实用儿科临床杂志，2015，30（10）：730-732.
|
| [14] |
赵秋会.高渗盐水联合布地奈德、沙丁胺醇对毛细支气管炎患儿肺功能的影响[J].临床医学研究与实践，2017，2（25）：99-100.
|
| [15] |
黄治华，余贵周，范徐威.高渗盐水与等渗盐水联合沙丁胺醇雾化吸入佐治小儿毛细支气管炎临床疗效的对比研究[J].实用心脑肺血管病杂志，2015，23（6）：90-93.
|
| [16] |
吴峰.雾化吸入高渗盐水联合布地奈德治疗毛细支气管炎临床观察[J].宁夏医科大学学报，2016，38（9）：1056-1058.
|
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