血浆D-二聚体及纤维蛋白原检测在诊断弥散性血管内凝血方面疾病的临床意义

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Abstract Objective To investigate the clinical value of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation(DIC).Methods A total of 30 DIC patients admitted into our hospital from January 2014 to May 2017 were selected as the observation group.The other 30 healthy women for physical examinations were enrolled in the same period as the control group A and another 30 normal pregnant women with suspected DIC was classified into the control group B.The plasma D-dimer and fibrinogen levels were compared among the three groups.Results Before treatment,the levels of plasma D-dimer and fibrinogen in the observation group were(2301.52±1367.94)μg/L and (1.23±0.34)g/L respectively,while those in the control groups A and B were(143.67±35.12)μg/L and(2.76±0.47)g/L,and(874.98±451.20)μg/L and (2.11±0.36)g/L accordingly.The D-dimer level in the observation group was significantly higher,but fibrinogen was lower than those in the other two groups,with statistical differences(P＜0.05).The D-dimer level in the control group B was higher compared to the control group A,the fibrinogen level of the control group B was lower compared to the control group A,with statistical significance (P＜0.05).Conclusion The detections of plasma D-dimer and fibrinogen have high clinical values in the diagnosis of DIC and the diagnostic sensitivity is strong,which is worthy of clinical application and promotion.

Key words： D-dimer Fibrinogen Disseminated intravascular coagulation Diagnosis Value

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	Articles by authors
	CAI Jin-mei
	HUANG Xue-zhen
	ZHANG Rui-xiong
	WU Sheng-xing

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CAI Jin-mei,HUANG Xue-zhen,ZHANG Rui-xiong, et al. Clinical significance of detection of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation[J]. 中国当代医药, 2018, 25(9): 114-116.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I9/114

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