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| Influence of different doses of Oxycodone on catheter-related bladder discomfort during recovery from general anesthesia |
| DENG Jian-ping1 JIAO Shou-feng2 YANG Yu-jun3 LUO He-guo1▲ |
| 1.Department of Anesthesiology,the Third Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330006,China;2.Department of Pharmacy,the Third Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330006,China;3.Medical College of Nanchang University,Jiangxi Province,Nanchang 330006,China |
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Abstract Objective To investigate the influence of different doses of Oxycodone on catheter-related bladder discomfort(CRBD)during recovery from general anesthesia in patients.Methods Ninety male patients with radical gastrectomy for gastric cancer from January to December 2017 in our hospital were selected and divided into the control group,the low dose group and the high dose group according to random number table method,30 cases in each group.Before the end of the operation,the low dose group was intravenously injected with 0.05 mg/kg Oxycodone,and the high dose group was injected with 0.1 mg/kg Oxycodone,and the control group was injected with the same dose of normal saline.The operation condition and hemodynamic changes,Ricker sedation agitation score and CRBD occurrence were recorded during anesthesia recovery stage between the three groups.Results The MAP and HR in the low and high dose group were lower than that in control group,the level of SpO2in the low and high dose group was higher than that in control group at T2and T3,and the MAP and HR in the high dose group were lower than those in the low dose group,the SpO2in the high dose group was higher than that in the low dose group,and the difference was statistically significant(P＜0.05).At T1,there was no significant difference in Ricker sedation-agitation score among the three groups(P＞0.05).At T2and T3,the Ricker sedation agitation score of the low and high group was significantly lower than that of the control group,and the Ricker sedation agitation score of the high dose group was significantly lower than the low dose group,with significant difference(P＜0.05).The degree of CRBD in the low dose group was less than that of the control group,and the degree of CRBD in the high dose group was lower than that in the low dose group,and the difference was statistically significant(P＜0.05).Conclusion Oxycodone of 0.1 mg/kg can effectively prevent catheter related bladder irritation during general anesthesia recovery period.
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