利伐沙班预防老年股骨粗隆间骨折术后深静脉血栓形成的效果

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Abstract Objective To explore the effect of Rivaroxaban in prevention of post-operative deep venous thrombosis(DVT)after intertrochanteric fracture of femur in elderly patients.Methods Altogether 80 elderly patients with intertrochanteric fractures of femur who were treated in our hospital from November 2015 to April 2017 were selected as the subjects,and divided into two groups according to the random number table method,with 40 cases in each group.The Rivaroxaban group was treated with Rivaroxaban Tablets,while the low molecular weight heparin calcium(LMWHC)group were administered with injection of LMWHC.The coagulation indexes before operation and at postoperative 1 and 12 hours,including platelet(PLT),alanine aminotransferase(ALT)and activated partial thromboplastin time (APTT),as well as intra-operative hemorrhage,post-operative drainage and post-operative deep vein thrombosis(DVT)incidence of two groups were observed.Results The PLT and APTT levels of the two groups at post-operative 1 and 12 hours were lower than those before operation,and the ALT levels of the two groups was higher than that before operation,with statistically significant difference(P<0.05).There were no statistically significant differences in the levels of PLT,APTT and ALT between the two groups at post-operative 1 and 12 hours(P>0.05).There were no statistically significant differences in intra-operative hemorrhage and drainage volume between the two groups(P>0.05).All the patients were followed up for 6 months.The incidence of DVT of Rivaroxaban group was 2.5%,lower than that of LMWHC group,with statistically significant difference (P<0.05).Conclusion Application of Rivaroxaban in the treatment of elderly patients with intertrochanteric fracture of femur has little effect on coagulation function,and can significantly reduce the incidence of post-operative DVT.

Key words： Rivaroxaban Low molecular weight heparin calcium Intertrochanteric fracture of femur Deep venous thrombosis Clinical efficacy

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	YAN Jian-hua
	XIE Qing

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YAN Jian-hua,XIE Qing. Effect of Rivaroxaban in prevention of post-operative deep venous thrombosis after intertrochanteric fracture of femur in elderly patients[J]. 中国当代医药, 2018, 25(28): 109-112.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I28/109

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