氟比洛芬酯和帕瑞昔布钠注射液在骨科手术超前镇痛及术后镇痛中的效果对比

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Abstract Objective To explore and analyze the effect of Flurbiprofen Axetil and Parecoxib Sodium injection on preemptive analgesia and postoperative analgesia in orthopedic surgery.Methods A total of 150 patients with orthopaedic surgery in our hospital from July 2016 to August 2017 were selected,and divided into the two groups according to the random number table,and there were 75 cases in each group.In control group,at 15 min before operation,the observation group was treated with Flurbiprofen Axetil and the control group was treated with Parecoxib Sodium.Pain score,serum inflammatory factors and adverse reactions were compared between the two groups.Results The pain scores at 6,12,24 h after operation in the two groups were significantly lower than those immediately after operation (P<0.05),the pain score of the observation group was lower than that of the control group at different time points after operation (P<0.05).The serum levels of inflammatory factors in the two groups 24 hours after operation were significantly higher than those before operation(P<0.05).There was no significant difference in serum TNF-α,IL-6 and CRP level between the two groups before operation (P>0.05).The level of serum TNF-α,IL-6 and CRP in the observation group were significantly lower than those in the control group 24 hours after operation (P<0.05).The total incidence of adverse reactions in the observation group was 6.67%,which was lower than that in the control group (20.00%)(P<0.05).Conclusion Preemptive analgesia with Flurbiprofen Axetil for orthopaedic surgery patients can effectively alleviate postoperative pain,alleviate inflammatory reaction in vivo and reduce the occurrence of adverse reactions,which is worthy of promotion and application.

Key words： Flurbiprofen Axetil Parecoxib Sodium Orthopedic surgery Preemptive analgesia Effection

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	LI Min
	DONG Mei-rong
	YU Chang
	LIN Li

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LI Min,DONG Mei-rong,YU Chang, et al. Effect comparison of Flurbiprofen Axetil and Parecoxib Sodium injection in preemptive analgesia and postoperative analgesia in orthopedic surgery[J]. 中国当代医药, 2018, 25(26): 128-130.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I26/128

[1]	贾秀眉，兰丽琴，汤礼贵.氟比洛芬酯对骨科手术超前镇痛及术后镇痛的临床疗效评价[J].中国临床药理学杂志，2016，32（2）：150-152.
[2]	闫彩云，徐璟琦，贾若，等.氟比洛芬酯超前镇痛联合小剂量咪达唑仑镇静在老年患者下肢骨折复位内固定手术中应用[J].湖南中医药大学学报，2016，36（A02）：817-818.
[3]	孙搏，林英，张晶璟，等.非甾体抗炎药在骨科手术超前镇痛中的临床应用研究[J].现代生物医学进展，2016，16（14）：2655-2659.
[4]	田明，杨伟伟，王楠.地佐辛复合氟比洛芬酯超前镇痛对高龄全髋关节置换术后镇痛效果观察[J].陕西医学杂志，2015，44（3）：363-364.
[5]	金宏.骨科手术患者采用氟比洛芬酯超前镇痛的术后镇痛效果观察[J].浙江创伤外科，2017，22（3）：613-614.
[6]	闫期，安翠红，杨小丰，等.超前镇痛对干预下肢骨科手术术后深静脉血栓形成的作用[J].血栓与止血学，2017，23（5）：833-835.
[7]	高凯，王晓飞，王苗.氟比洛芬酯用于骨科手术超前镇痛的效果及不良反应观察[J].陕西医学杂志，2016，45（1）：78-80.
[8]	闫彩云，徐惠青，徐璟琦，等.氟比洛芬酯超前镇痛对下肢骨科手术老年患者术后认知功能及白细胞水平的影响[J].广东医学，2017，38（6）：952-954.
[9]	杜璠，刘延雄，刘志斌，等.氟比洛芬酯与氯诺昔康用于膝关节微骨折术超前镇痛的效果对比[J].创伤外科杂志，2017，19（1）：58-61.
[10]	林鹰.氟比洛芬酯超前镇痛对老年患者骨科手术术后镇痛的影响[J].当代医学，2016，22（31）：140-141.
[11]	王晓飞，高凯，马跃.骨科手术患者应用氟比洛芬酯超前镇痛的临床意义[J].陕西医学杂志，2016，45（6）：709-710.
[12]	程财清，任何，施镔，等.帕瑞昔布超前镇痛联合术后硬膜外镇痛应用于髋关节置换术患者的临床观察[J].中国药房，2017，28（11）：1518-1522.
[13]	汪海钢，王伟东，徐丽丽，等.氟比洛芬酯术中预注对老年髋关节置换术患者术后血浆S-100B蛋白、NSE浓度及认知功能的影响[J].中国现代医生，2017，55（24）：104-107.
[14]	邓雪峰.氟比洛芬酯注射液用于老年髋关节置换术患者超前镇痛的临床研究[J].中国临床药理学杂志，2017，33（18）：1771-1772，1784.
[15]	陈琳，王艳玲，王建珍.骨科手术中帕瑞昔布钠复合地佐辛超前镇痛效果观察[J].山东医药，2015，55（5）：49-51.