2型糖尿病与骨质疏松的关系研究

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Abstract Objective To study the relationship between type 2 diabetes(T2DM)mellitus and osteoporosis.Methods From September 2015 to February 2017,96 patients with T2DM mellitus who were treated in our hospital were divided into two groups:blood glucose control group(n=48)and blood glucose control substandard group(n=48).In addition,48 healthy patients in the same period were selected as the control group.At the same time,96 patients with diabetes mellitus were divided into osteoporosis group(n=37),normal group(n=13),and bone mineral density decrease(n=46)according to the degree of osteoporosis three groups were divided into three groups：25(OH)D3 （25 hydroxyvitamin D3）,blood calcium,Urine calcium,serum magnesium and PTH (parathyroid hormone),course of diabetes and HbA1c(glycosylated hemoglobin)were compared.Results①25(OH)D3 in blood glucose control group was lower than that in control group,serum magnesium was lower than that in control group and the urinary calcium index was higher than that in control group.The differences were statistically significant(P＜0.05）,25(OH)D3,ALP,serum magnesium in blood glucose control substandard group were lower than those in the control group,and the urinary calcium index was higher than that in the control group.The differences were statistically significant(P＜0.05）.②PTH,course of diabetes and HbA1c in osteoporosis group were significantly higher than those in control group and BMD decrease,the differences were statistically significant(P＜0.05）.③The independent risk factors for the decrease of bone mineral density in diabetes mellitus were significan PTH,the course of diabetes and HbA1c and 25(OH)D3.Conclusion There was a significant correlation between T2DM and osteoporosis.The course of diabetes and the effect of HbA1c and 25(OH)D3 on the bone mineral density of type 2 diabetes mellitus.

Key words： Osteoporosis type 2 diabetes mellitus Bone mineral density

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	Articles by authors
	ZHU Zhi-cheng
	DU Ling-chao
	GUOCai-xia

Cite this article:

ZHU Zhi-cheng,DU Ling-chao,GUOCai-xia. Study on the relationship between type 2 diabetes mellitus and osteoporosis[J]. 中国当代医药, 2018, 25(24): 53-55.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I24/53

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