大剂量环磷酰胺辅助治疗肾病综合征型紫癜性肾炎患儿的临床效果

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Abstract ObjectiveTo investigate the effect of high dose Cyclophosphamide combined with prednisone in children with nephrotic syndrome and purpura nephritis.Methods60 cases of nephrotic syndrome type purpura nephritis were selected from February 2014 to March 2016.According to the random number table method,the control group and the study group were divided into 30 cases.The control group was treated with strong pine treatment,the study group to give high-dose Cyclophosphamide combined with prednisone treatment.Compared of the clinical efficacy of the two groups,24 h urinary protein,peripheral white blood cell(WBC)count,urine red blood cell count,total cholesterol(TC），triglyceride（TG）,serum creatinine(Scr),blood urea nitrogen(BUN),plasma albumin(ABL),extra renal symptoms and adverse reaction should the occurrence.ResultsThe total remission rate of the study group(93.33%)was significantly higher than that of the control group(66.66%)(P＜0.05).After intervention,the levels of 24 h urinary protein,TG,Scr,BUN,TC,and urine red blood cell count in the study group were significantly different from those in the control group(P＜0.05).After the intervention,the proportion of Cushing syndrome in the study group was significantly less than that in the control group(P＜0.05),and the proportion of microscopic hematuria was significantly smaller than that of the control group(P＜0.05).ConclusionHigh dose Cyclophosphamide combined with prednisone in the treatment of children with nephrotic syndrome type purpura nephritis curative effect is exact,less adverse reactions in patients,can significantly improve renal function.

Key words： Nephrotic type Purpura nephritis Cyclophosphamide Prednisone

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	ZOU Xian
	LI Jian-wei

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ZOU Xian,LI Jian-wei. Clinical effect of high-dose Cyclophosphamide in the treatment of nephrotic syndrome children with Henoch Schonlein purpura nephritis[J]. 中国当代医药, 2018, 25(2): 71-73.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I2/71

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