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Application analysis of Alprostadil Injection in elderly acute renal injury |
BIAN Xiao-yan GONG Chun-shui LIANG Meng GU Xiao-ling SUN Qi |
Department of Nephrology,the 174thHospital of PLA,Fujian Province,Xiamen 361000,China |
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Abstract Objective To analyze the application effect of Alprostadil Injection on acute renal injury in the elderly.Methods From January 2015 to January 2017,98 patients with acute renal injury in our hospital were selected and randomly divided into the control group and the study group,49 cases in each group.The control group was given conventional specialist treatment,the study group was treated with Alprostadil Injection on the basis of the control group.The levels of BUN,SCr,NAG,β2-MG before and after treatment and the therapeutic effect,oliguria duration,SCr recovery time were compared between the two groups.Results There was no significant difference in the levels of BUN,SCr,NAG and β2-MG between the two groups(P>0.05).The levels of BUN,SCr,NAG and β2-MG in the two groups after treatment was lower than that before treatment,the levels of BUN,SCr,NAG and β2-MG in the study group after treatment was lower than that in the control group,with significant difference (P<0.05).The total effective rate of the study group was 91.84%,which was significantly higher than that of the control group (75.51%),with significant difference(χ2=4.780,P=0.029).The oliguria duration,SCr recovery time in the study group was (5.4±2.0),(7.2±2.9)days,respectively,which was significantly shorter than that in the control group[(6.9±2.0),(9.5±4.0)days],with significant difference(P<0.05).Conclusion The application effect of Alprostadil Injection in acute renal injury in elderly patients is remarkable,which is worthy of promotion and application.
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[3] |
衣利,林棱,姚瑾.前列地尔注射液治疗老年急性肾损伤的临床研究[J].现代诊断与治疗,2015,26(2):398.
|
[4] |
袁惠敏,杨卫红,范臻.前列地尔注射液治疗老年UAP患者的临床疗效及其机制[J].山东医药,2012,52(29):76-77.
|
[5] |
林秋燕,曹木根.前列地尔注射液联合还原型谷胱甘肽治疗老年急性肾损伤的临床观察[J].海峡药学,2016,28(4):129-130.
|
[6] |
张浩明,汪蓉,郭秀平.前列地尔强化治疗对老年患者心脏术后急性肾损伤的保护作用[J].海军医学杂志,2014,35(6):449-451.
|
[1] |
Branch-Elliman W,Ripollone JE,O′Brien WJ,et al.Risk of surgical site infection,acute kidney injury,and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone:a national propensity-score-adjusted retrospective cohort study[J].PLoS Med,2017,14(7):1002340.
|
[7] |
武欣迎,李晶晶,顾晔,等.前列地尔注射液辅助治疗急性心肌梗死后急性肾损伤 37例[J].医药导报,2013,32(4):476-477.
|
[8] |
崔俊.丹参酮ⅡA磺酸钠联合前列地尔对急性肾损伤患者的临床治疗效果研究[J].黑龙江医药,2016,29(4):679-681.
|
[2] |
Yuan W,Zhang YY,Zhang ZG,et al.Risk factors and outcomes of acute kidney injury in patients with hepatitis B virus-related acute-on-chronic liver failure[J].Am J Med Sci,2017,353(5):452-458.
|
[9] |
范建军,李更新,李敬文,等.前列地尔注射液对老年患者冠脉介入治疗术后对比剂肾病的预防[J].实用医学杂志,2016,32(7):1164-1166.
|
[10] |
廉开胜,曾丽.前列地尔联合甲泼尼龙治疗克林霉素所致急性肾损伤的临床研究[J].中国中西医结合肾病杂志,2012,28(8):738-739.
|
[11] |
郑剑武,徐正明,黄世恩,等.前列地尔注射液在造影剂肾病中的预防作用[J].浙江中西医结合杂志,2015,25(8):772-773.
|
[12] |
陈湘华,杨京新,杨璞,等.老年慢性肾脏疾病并发急性肾损伤的临床特点及危险因素分析[J].齐齐哈尔医学院学报,2015,36(17):2529-2530.
|
[13] |
李锦玉,李波,李萌和,等.前列地尔治疗老年急性肾损伤的临床疗效[J].中国现代药物应用,2017,11(3):117-118.
|
[14] |
Güneysu E,Kocman AE,Ozatik O,et al.The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation,tissue degeneration,and apoptosis in rat skeletal muscle[J].Turk J Med Sci,2017,47(3):1028-1036.
|
[15] |
刘向东.前列地尔注射液治疗老年急性肾损伤的疗效[J].中国老年学,2013,33(8):1904-1906.
|
|
|
|