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| Research progress on reversal of multidrug resistance in leukemia cells by traditional Chinese medicine |
| LIN Ting1, LIAO Bin2▲ |
1.Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350122,China;
2.Department of Hematology,People Hospital Affiliated to Fujian University of Traditional Chinese Medical,Fujian Province,Fuzhou 350004,China |
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Abstract The main reason of causing failure of chemotherapy and disease recurrence is multidrug resistance (MDR).Because the mechanism of tumor cell MDR action is very complex,traditional Chinese medicine can reverse MDR with multiple targets,multiple pathways,low toxicity and high efficiency.As a drug resistance reversal agent,traditional Chinese medicine has become a hot topic that it enhances the sensitivity of drug-resistant tumor cells to chemotherapeutic drugs.This article reviews the research of the complex mechanism of tumor cell MDR and the reversal of MDR by single traditional Chinese medicine and compound traditional Chinese medicine.
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Received: 05 June 2017
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|
| [2] |
Yergeri M,Kapse-Mistry S,Srivastava R, et al .Nanodrug delivery in reversing multidrug resistance in cancer cells[J].Front Pharmacol,2014,5：159.
|
| [9] |
陈宝安,李静,程坚,等.汉防己甲素联合柔红霉素对K562/AO 2 细胞株P21蛋白和P糖蛋白表达的影响[J].中国实验血液学杂志,2009,17（5）：1179-1182.
|
| [10] |
何海兰,季丽娟,李琦智,等.槲皮素对阿霉素诱导HL-60细胞MDR1基因表达的影响[J].中国实验血液学杂志,2015,23（1）：70-76.
|
| [11] |
韩艳秋,曹林娟,郝洪军,等.槲皮素逆转白血病细胞系K562/A多药耐药性及相关基因表达的研究[J].中国实验血液学杂志,2011,19（4）：884-889.
|
| [12] |
黄明,孟凡义,蔡艳霞,等.三氧化二砷逆转HL60/ADR细胞耐药的研究[J].中国组织工程研究与临床康复,2011, 15（19）：3518-3521.
|
| [1] |
Kunjachan S,Rychlik B,Storm G, et al .Multidrug resistance：physiological principles and nanomedical solutions[J].Adv Drug Deliv Rev,2013,65（13-14）：1852-1865.
|
| [3] |
Wang YJ,Zhang YK,Kathawala RJ, et al .Repositioning of tyrosine kinase inhibitors as antagonists of ATP-binding cassette transporters in anticancer drug resistance[J].Cancers,2014,6（4）：1925-1952.
|
| [4] |
Wang YJ,Li Q,Xiao HB, et al .Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway[J].Drug Des Devel Ther,2015,9：5301-5313.
|
| [13] |
宋庆林,江梅.苦参碱对白血病HL-60细胞增殖、凋亡及其Bcl-2 mRNA、Survivin mRNA表达的影响[J].山东医药,2014,54（15）：30-32.
|
| [14] |
桂琳,李静,陈宝安,等.环氧合酶-2抑制剂联合苦参碱逆转K562/AO 2 细胞多药耐药的研究[J].东南大学学报（医学版）,2012,31（2）：174-178.
|
| [15] |
黄燕芬,董改霞,洪行球,等.姜黄素水解物对K562/AO2细胞多药耐药的逆转作用研究[J].中国中药杂志,2010, 35（18）：2460-2463.
|
| [16] |
王婷,双跃荣,庄小捷,等.川芎嗪联合三氧化二砷逆转K562/ADM细胞多药耐药的实验研究[J].实用癌症杂志,2009,24（2）：121-124,134.
|
| [5] |
Yu P,Cheng X,Du Y, et al .Significance of MDR-related proteins in the postoperative individualized chemotherapy of gastric cancer[J].J Cancer Res Ther,2015,11（1）：46-50.
|
| [6] |
Lee SK,Shehzad A,Jung JC, et al .Protein kinase Cα protects against multidrug resistance in human colon cancer cells[J].Mol Cells,2012,34（1）：61-69.
|
| [7] |
Zhang X,Dong W,Zhou H, et al .Alpha-2,8-sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt rathway in humanchronic myeloid leukemia[J].IUBMB Life,2015,67（2）：77-87.
|
| [8] |
Gisel A,Valvano M,El II, et al .miRNAs for the detection of multidrugresistance：overview and perspectives[J].Molecules,2014,19（5）：5611-5623.
|
| [17] |
秦小清,梁宇光,高洪志,等.五味子甲素对K562/ADR、HL60/ADR、MCF-7/ADR多药耐药逆转机制的研究[J].中国药理学通报,2011,27（3）：329-334.
|
| [18] |
王天晓,王世广,时小燕,等.小檗碱增强K562/DOX细胞对多柔比星敏感性的研究[J].中国药学杂志,2013,48（6）：431-435.
|
| [19] |
廖斌.中药复方君子汤对白血病细胞株K562/VCR耐药性的逆转作用[J].福建中医药大学学报,2011,21（4）：9-12.
|
| [20] |
马武开,姚血明,李玉莹,等.解毒化淤药对白血病K562/AO2、HL60/Adr细胞P-gp、Bcl-2、P53基因表达影响的研究[J].时珍国医国药,2011,22（10）：2321-2323.
|
| [21] |
马武开,姚血明,王莹,等.解毒化瘀方对白血病K562/AO2细胞耐药逆转作用及NF-κB信号表达的影响[J].中华中医药杂志,2012,27（5）：1394-1397.
|
| [22] |
严鲁萍,张伟玲,姚宇红,等.益气养阴解毒方对K562/AO 2 裸鼠移植瘤逆转作用研究[J].中华中医药杂志,2011,26（9）：2137-2139.
|
| [23] |
陈信义,郑智,陈菊,等.复方浙贝颗粒联合阿霉素对K562/AO2移植瘤细胞凋亡及相关蛋白表达的影响[J].中国实验血液学杂志,2009,17（6）：1439-1442.
|
| [24] |
史哲新,杨文华,汤毅,等.六神丸逆转白血病细胞多药耐药作用及相关机制研究[J].天津中医药大学学报,2007,26（1）：11-13.
|
| [25] |
李海燕.六神丸及其成分蟾酥对K562/DOX细胞的增殖和MDR1基因表达的影响[J].辽宁中医杂志,2012,39（27）：1409-1410.
|
|
|
|
