|
|
Feasibility analysis of Compound Glycyrrhizin on desloratadine Citrate in the treatment of chronic urticaria |
ZENG Dong-wu1 WU Hui-jian1 HUANG Bao-zhen2 CHEN Yan-fang3 XIE Zhi-hua4 |
1.Department of Dermatology,People′s Hospital of Lianzhou City of Qingyuan City in Guangdong Province,Lianzhou 513400,China;
2.Department of Clinical Laboratory,People′s Hospital of Lianzhou City of Qingyuan City in Guangdong Province,Lianzhou 513400,China;
3.Department of Obstetrics and Gynecology,People′s Hospital of Lianzhou City of Qingyuan City in Guangdong Province,Lianzhou 513400,China;
4.Department of Surgery,People′s Hospital of Lianzhou City of Qingyuan City in Guangdong Province,Lianzhou 513400,China |
|
|
Abstract ObjectiveTo investigate the clinical effect of Compound Glycyrrhizin on desloratadine citrate in the treatment of chronic urticaria.Methods180 cases of chronic urticaria from January 2015 to December 2016 in our hospital were selected and randomly divided into the control group and the study group,90 patients in each group.The control group was treated with Desloratadine Citrate,the study group was treated with Compound Glycyrrhizin combined with Desloratadine Citrate.The clinical efficacy,onset time,symptom disappearance time,adverse reaction,peripheral blood T lymphocyte subsets,IgE and EOS levels were compared between the two groups.ResultsThe clinical effective rate of the study group(92.22%)was significantly better than that of the control group(78.88%)(P<0.05).The onset time and symptom disappearance time in the study group was significantly shorter than that in the control group(P<0.05).The improvement of peripheral blood T lymphocyte subsets,IgE and EOS levels in the study group was significantly better than that in the control group (P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).ConclusionIn the treatment of patients with chronic urticaria in Compound Glycyrrhizin Combined with Desloratadine Citrate treatment can significantly shorten the treatment time of patients,improve the peripheral blood T cell subsets,IgE,EOS,and safe and effective,it is worthy of promotion and application.
|
|
|
|
|
[1] |
闫毅,刘瑞珍,徐德钢.枸地氯雷他定与依匹斯汀治疗慢性荨麻疹随机对照研究[J].中华皮肤科杂志,2015,48(1):54-56.
|
[2] |
李国邦,薛强东,唐祁平.地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹的临床观察[J].医学研究杂志,2015,44(1):150-153.
|
[3] |
董东,何小亮,杨德勇,等.枸地氯雷他定与阿伐斯汀递减疗法治疗慢性荨麻疹的疗效比较[J].中国药房,2015,26(36):5078-5080.
|
[4] |
周顺龙,许恩超,邓雯,等.氯雷他定联合地氯雷他定治疗儿童慢性自发性荨麻疹的临床观察[J].中华皮肤科杂志,2017,50(1):46-48.
|
[5] |
赵晓明.枸地氯雷他定结合复方甘草酸苷治疗慢性湿疹106 例疗效观察[J].吉林医学,2015,36(4):700-701.
|
[6] |
叶霞.复方甘草酸苷联合地氯雷他定治疗慢性荨麻疹疗效观察[J].中国临床实用医学,2010,10(2):7330.
|
[7] |
熊学坤,王雪严.地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹 58 例效果观察[J].中外医学研究,2016,14(6):55-56.
|
[8] |
臧娅群.地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹的临床观察[J].吉林医学,2017,38(2):366-367.
|
[9] |
王朵勤,唐慧,沈燕芸,等.慢性荨麻疹患者血浆D二聚体、活化凝血因子Ⅶ及活化凝血因子Ⅻ水平的研究[J].中华皮肤科杂志,2015,48(1):37-40.
|
[10] |
俞杰.多药物联合治疗96例慢性荨麻疹效果及对IL-18、25 的影响[J].交通医学,2016,30(4):326-327.
|
[11] |
王加庆,高志宏.复方甘草酸苷联合地氯雷他定治疗慢性荨麻疹[J].现代中西医结合杂志,2009,18(21):2562.
|
[12] |
陈明春,罗汉权.慢性荨麻疹临床表现与白细胞介素-31的关系[J].广东医学,2016,37(S2):55-56.
|
[13] |
白明辉.枸地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹临床研究[J].中国麻风皮肤病杂志,2016,32(9):546.
|
[14] |
王会民,李丽.复方甘草酸苷联合枸地氯雷他定治疗慢性荨麻疹疗效观察[J].中国药物与临床,2013,13(S1):57-58.
|
[15] |
罗建华,肖汉龙,王军.复方甘草酸苷联合枸地氯雷他定治疗慢性荨麻疹[J].实用医药杂志,2011,28(8):697.
|
|
|
|