TGF-β与器官纤维化的研究进展

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Abstract Transforming growth factor-β(TGF-β)is a kind of growth factor which turn normal cellular into fibrosis,and it plays an important role in the process of renal tubule interstitial fibrosis.TGF-β has the characters that widely spreading and influence.There are 4 sub-types has been found at least in mammals and it could be produce by varieties of cell in human.It contains 2 signaling pathways that Smad and MAPK,and the critical functions are cell growth depression and enhancing the gathering of extracellular matrix.One of the reasons cause chronic renal failure is excessive ECM deposition when renal tubule switch to fibrosis.Renal interstitial fibrosis is the common pathway of various development of kidney disease to kidney failure and the pathologic basis of persistent liver damage can lead to liver fibrosis and cirrhosis caused by large area.The renal interstitial fibrosis and hepatic fibrosis,TGF-beta also played a very important role.This paper aims at about TGF-beta function,TGF-beta receptor signal transduction pathway and renal tubule fibrosis and liver fibrosis related quality progress were discussed,and the TGF-beta receptor in clinical application are briefly discussed.

Key words： Transforming growth factor-&beta Renal tubule interstitial fibrosis Liver fibrosis Extracellular matrix Cellular signal transduction

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	Articles by authors
	ZUO Kui-yang
	CHEN Meng-xi
	MENG Na-na
	JIN Xiu-dong
	LIU Hai-feng

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ZUO Kui-yang,CHEN Meng-xi,MENG Na-na, et al. Research progress of TGF-β and organ fibrosis[J]. 中国当代医药, 2017, 24(17): 12-16.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I17/12

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