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A study between ferritin and insulin resistance and its sex differences in type 2 diabetes mellitus |
ZHANG Wei |
Department of Endocrinology,Nanchang Hospital of Integrated Traditional Chinese and Western Medicine in Jiangxi Province,Nanchang 330003,China |
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Abstract ObjectiveTo investigate the correlation between serum ferritin(SF)and insulin resistance and its sex differences in patients with type 2 diabetes mellitus(T2DM).Methods49 patients with T2DM treated in our hospital of department of endocrinology from July 2014 to December 2015 were selected.According to the sex,patients were divided into the male group including 25 patients and the female group including 24 patients.50 healthy subjects receiving physical examination at the same period were included in the control group.Total cholesterol(TC),triglyceride (TG),low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),C-reactive protein(CRP),HbA1c,fasting insulin(FINS),SF,and fasting plasma glucose(FPG)were detected in various group.ResultsTC,TG,LDL-C,HDL-C,CRP, HbA1c,FBG,FINS,SF,and homeostasis model assessment-insulin resistance(HOMA-IR)were significantly higher in the T2DM group than in the control group(P<0.05).SF presented positive correlation with TC,TG,LDL-C,and FBG(P<0.05), and significant positive correlation with HbA1c,HOMA-IR,FINS,and CRP(P<0.01).The correlation between HOMA-IR and SF was higher in male patients than in female patients with T2DM.ConclusionSF is elevated in patients with T2DM,and to some extent correlated with insulin resistance.The correlation between HOMA-IR and SF in male patients is more better.
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[1] |
Yang W,Lu J,Weng J,et al.Prevalence of diabetes among men and women in China[J].New Engl J Med,2010,362(20):1090-1101.
|
[2] |
范慧,张鹏睿,徐援.2型糖尿病合并非酒精性脂肪肝与胰岛素抵抗及心血管病变发生的关系研究[J].中国全科医学,2011,14(2):147-150.
|
[3] |
谢新荣.2型糖尿病患者体重指数与胰岛素抵抗、血脂的关系[J].广西医学,2007,29(1):104-105.
|
[4] |
陈雨,郑少雄,郝杰,等.白介素6在2型糖尿病大鼠胰岛素抵抗中的作用[J].中国临床医学,2011,18(1):32-34.
|
[5] |
贾伟平,项坤三,陈蕾,等.上海地区40岁以上自然人群中胰岛素抵抗现状及特征分析[J].上海医学,2001,24(4):199.
|
[6] |
李秋云,王彩宁,史丽萍,等.2型糖尿病及前期患者胰岛素抵抗与脂代谢紊乱的关系[J].中国全科医学,2011,14(24):2716-2719.
|
[7] |
李彩艳,林凤平,赵辛元,等.血清铁蛋白与2型糖尿病的关系探讨[J].中国临床保健杂志,2016,19(4):354-356.
|
[8] |
魏剑芬,吴乃君,陈冬,等.糖尿病周围神经病变患者血清铁蛋白与氧化应激反应的相关性[J].广东医学,2014,35 (18):2887-2889.
|
[9] |
姜晓梅,梁燕敏,靳瑾,等.急性冠状动脉综合征患者血清铁蛋白水平变化及意义[J].山东医药,2015,55(3):1-2.
|
[10] |
臧丽,母义明.胰岛素抵抗机制的新认识[J].国际内分泌代谢杂志,2009,29(3):150-160.
|
[11] |
吴卫元,永青.铁蛋白增高对机体的不利影响[J].中国血液流变学杂志,2011,21(3):517-519.
|
[12] |
王瑞,刘小立,张木勋,等.机体铁代谢与2型糖尿病关系研究[J].营养学报,2008,30(6):561-564.
|
[13] |
Park SK,Ryoo JH,Kim MG,et al.Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men:a 5-year follow-up study[J].Diabetes Care,2012,35(12):2521-2526.
|
[14] |
李江源,李小鹰,李明,等.年龄依赖性胰岛素抵抗与睾酮水平的相关性[J].中华老年医学杂志,2007,26(2):104-106.
|
[15] |
刘宗慧,刘献忠,杨兴辉,等.2型糖尿病患者血清C反应蛋白与胰岛素抵抗[J].齐齐哈尔医学院学报,2012,33 (21):2883-2884.
|
[16] |
韩立坤,卢丹.血清铁蛋白与2型糖尿病关系的研究[J].中国实验诊断学,2007,11(10):1359-1361.
|
[17] |
柴旭兵.2型糖尿病患者血清铁蛋白水平与外周血管粥样硬化关系[J].中华实用诊断与治疗杂志,2016,30(10):993-995.
|
[18] |
陆明雪,刘红伟,吴景华.2型糖尿病合并颈动脉粥样硬化与超敏C反应蛋白及同型半胱氨酸的关系[J].中国临床研究,2015,28(10):1316-1318.
|
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