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| Screening of Chinese herbal medicine for antibacterial anti-inflammatory in department of gynaecology and preclinical experimental study |
| ZUO Chun-lian1 HAN Cheng-yun2 LIU Zhi-kai2 YAN Qu-ru2▲ |
1.Department of Gynaecology and Obstetrics,Yuanzhou District Maternal and Child Health Hospital in Jiangxi Province, Yichun 336000,China;
2.Yichun University in Jiangxi Province,Yichun 336000,China |
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Abstract ObjectiveTo study the drug of treating gynecological reproductive system infection,and screen the Chinese herbal medicine with very good antibacterial anti-inflammatory effect.MethodsFour kinds of Chinese herbal medicines were selected as the antibacterial and antiphlogistic drugs∶Dendropanax dentiger Merr.,Lycopodium japonicum Thunb, Usnea diffracta Vain,Pholido-ta cantonensis Rolfe.They were extracted by water extraction and ethanol extraction,and then they were mixed into the same concentration solution.The group was the treatment group of Chinese herbal medicine(n=25),and water CK1 and ethanol CK2 control group(n=25)respectively.Escherichia coli,Staphylococcus aureus,Staphylococcus aureus were Cultured,and the bacteriostatic ring was determined of Chinese herbal medicine extract by tube plate method to evaluate the bacteriostatic effect.ResultsAmong 4 kinds of water extract of Chinese herbal medicine,Lycopodium japonicum Thunb had the best bacteriostatic effect,and it had a very obvious bacteriostatic effect for 3 kinds of bacteria,and there was a statistical difference compared with control group(P＜0.01),and bacteriostatic effect of Dendropanax dentiger Merr.was stronger for Staphylococcus aureus,and there was a statistical difference of bacteriostatic effect compared with control group (P＜0.05),Usnea diffracta Vain was following,and there was a statistical difference compared with control group (P＜0.05).Among 4 kinds of alcohol extract of Chinese herbal medicine,Dendropanax dentiger Merr.had the best bacteriostatic effect,and it had a very obvious bacteriostatic effect for 3 kinds of bacteria,and there was a statistical difference compared with control group (P＜0.05),and bacteriostatic effect of alcohol extract for Dendropanax dentiger Merr.and Usnea diffracta Vain was almost quite,and there was a tatistical difference compared with comtrol group(P＜0.05).ConclusionBacteriostatic effect of alcohol extract of Dendropanax dentiger Merr. and Usnea diffracta Vain and the water extract of Lycopodium japonicum Thunb is obvious which is suitable for external use in clinical obstetrics and gynecology.Oral water decoction juice of Dendropanax dentiger Merr.for oral admina has an antibacterial anti-inflammatory in clinic.
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| [1] |
曹秀贞，易为.产褥感染病原菌分布、耐药性及危险因素分析[J].中国妇幼保健，2014，29（13）：2017-2018.
|
| [2] |
孔莉敏.生殖道感染对胎膜早破及其妊娠结局的影响[J].中国妇幼保健，2016，31（6）：1225-1227.
|
| [3] |
司徒仪，杨家林.妇科专病中医临床诊治[M].北京：人民卫生出版社，2005：291-328.
|
| [4] |
谢宇，蒋红涛，周重建.精编神农本草经彩色图谱[M].海口：海南出版社，2016：186-239.
|
| [5] |
曲欢欢.连翘化学成分和生物活性研究[D].西安：西北大学，2008：61-69.
|
| [6] |
胡竟一，雷玲，余悦，等.连翘的抗炎解热作用研究[J].中药药理与临床，2007，23（3）：51-52.
|
| [7] |
吴国友.连翘药理作用研究进展[J].中医学报，2003，28 （10）：1508-1509.
|
| [8] |
张明发，沈雅琴.女贞子及其有效成分药理作用与皮肤科临床应用的进展[J].抗感染药学，2013，10（4）：258-264.
|
| [9] |
郑莉萍，王庭芳，熊礼燕，等.树参属植物化学成分及药理活性研究进展[J].药学实践杂志，2011，29（1）：4-7.
|
| [10] |
张东博.四种药用植物中生物碱类化学成分的结构及生物活性研究[D].兰州：兰州大学，2015.
|
| [12] |
He J，Chen XQ，Li MM，et al.Lycojapodine A，a novel alkaloid from Lycopodium japonicum[J].Org Lett，2009，11 （6）：1397-1400.
|
| [13] |
唐宇.藤石松生物碱成分及其生物活性的研究[D].上海：复旦大学，2013.
|
| [14] |
吐尔干乃义·吐尔逊.中国树花地衣中多糖和松萝酸的提取及抗菌、抗氧化活性研究[D].乌鲁木齐：新疆大学，2010.
|
| [11] |
Setzer，William N.Essential oil composition of Dendropanax gonatopodus from Monteverde，Costa Rica.An ab initio examination of aromadendrane sesquiterpenoids[J].Nat Prod Commun，2008，3（9）：1557-1561.
|
| [15] |
赵小钒.松萝酸的抑菌实验研究[J].食品科学，2000，11 （3）：42-44.
|
| [16] |
王小平，刘海江，甄蕾，等.松萝酸对金黄色葡萄球菌耐药质粒的消除作用[J].中药材，2006，29（1）：36-39.
|
| [17] |
温秀萍，林青青，杨成梓，等.药食两用石仙桃资源保护与开发利用[J].海峡药学，2015，27（6）：46-47.
|
| [18] |
凌志扬，房玉良.石斛的化学成分及药理作用[J].中国当代医药，2012，19（5）：13-17.
|
|
|
|
