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Analysis of the clinical efficacy and safety of Gem citabine combined with Capecitabine in the treatment of advanced breast cancer with Anthracycline resistance |
GUOQing-sen |
The 95thHospital of PLA,Fujian Province,Putian 351100,China |
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Abstract ObjectiveTo explore the clinical efficacy and safety of Gemcitabine combining with Capecitabine in the treatment of advanced breast cancer with Anthracycline resistance.MethodsFrom June 2013 to November 2015,79 patients definitely diagnosed as advanced breast cancer with Anthracycline-resistant in our hospital were enrolled in the study and randomly assigned to control group (n=39)and observation group (n=40).In the control group,patientswere treated with Docetaxel and Capecitabine,while in the observation group,Gemcitabine combined with Capecitabine was used.After 2 cycles of treatment,the difference of clinical curative effect,the digestive tract discomfort inⅢandⅣdegrees and the occurrence of side effects such as bonemarrow suppression were compared between the two groups.ResultsThe total remission rate in the observation group was 47.50%,was higher than that in the control group (25.64%), the difference was statistically significant(P<0.05);the clinical total benefit rate in the control group was 76.92%,while the observation group was 80.00%,had no statistically significant difference between two groups(P>0.05);the incidence of digestive tract discomfort in degreeⅢ andⅣ and myelosuppression in the observation group was 17.50%and 22.50%,was lower than those of the control group (38.46%,43.59%),and the overall incidence of the digestive tract discomfort in degreeⅢandⅣand myelosuppression between the two groups had statistically significant difference (P< 0.05).ConclusionCombination of Gemcitabine and Capecitabine in the treatment of advanced breast cancer with Anthracycline-resistanthas a great effect,with few adverse reactions,it isworthy of promotion.
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