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Clinical study of transcatheter arterial chemoembolization combined with Sorafenib in the treatment of primary hepatic carcinoma |
BI Da-peng1 ZHANG Xiao-xiao2 |
1.The Sixth Ward,Tumor Hospital of Anshan City,Liaoning Province,Anshan114036,China;
2.The 12thWard,Tumor Hospital of Anshan City,Liaoning Province,Anshan114036,China |
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Abstract Objective To evaluate the clinical efficacy of transcatheter arterial chemoembolization(TACE)combined with Sorafenib in the treatment of primary hepatic carcinoma.Methods One hundred and fourteen patients with advanced primary hepatic carcinoma admitted in Tumor Hospital of Anshan City from January 2009 to April 2011 were randomly divided into experimental group and control group,57 cases in each group.Patients of the experimental group were treated with TACE combined with Sorafenib,and patients of the control group were treated with TACE alone.The therapeutic effect,concentration of AFP,and Karnofsky score of the two groups were observed;adverse reaction,skin reaction and 5-year survival rate were observed.Results The total effective rate in the experimental group(73.68%)was significantly higher than that in the control group(49.12%)(P<0.01).After treatment,the AFP concentration and Karnofsky score of the two groups were significantly improved compared with before treatment,and the experimental group was better than the control group(P<0.01).During the treatment,there was no serious adverse reactions were observed in the two groups.The incidence of skin reaction in the experimental group(64.9%)was significantly higher than that in the control group(10.5%)(P<0.01).The 5 years survival rate of the patients in the trial group was higher than that in the control group(P<0.01).Conclusion The treatment of primary hepatic carcinoma with hepatic arterial chemoembolization combined with Sorafenib can achieve significant short-term effect.The changes of AFP concentration and Karnofsky score after treatment are improved significantly.The adverse effect is mild,long-term outcomes is satisfactory,is worthy of clinical promotion vigorously.
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