胸腔镜微创手术对早期周围型肺癌患者术后炎症反应和免疫功能的影响

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Abstract Objective To observe the effect of radical surgery thoracoscope on TNF alpha,ⅠL-6,ⅠL-10 and the level of T lymphocyte subsets of patients with early peripheral lung cancer.Methods 78 patients with diagnosed early peripheral lung cancer in our hospital from August 2012 to December 2015 underwent surgery were included in the study and divided into open chest surgery group(n=40)and thoracoscopic group(n=38),patients in the open chest surgery group were treated with conventional thoracotomy,while patients in the thoracoscopic group underwent thoracoscopic resection of early peripheral lung cancer.Change of TNF alpha,ⅠL-6,ⅠL-10 in two groups were compared,and general situation and the differences in the levels of T lymphocyte subsets were compared.Results The level of TNF alpha,ⅠL-6,ⅠL-10 of two groups both improved(P＜0.05),while change of thoracoscopic group was lower(P＜0.05);intraoperative bleeding was less,hospitalization time,drainage tube indwelling time in the thoracoscopic group was shorter,postoperative ambulation time was earlier,and the differences were statistically significant(P＜0.05),there was no statistically significant differences in operative time(P＞0.05);fluctuation amplitude of CD3,CD4,CD8,CD4/CD8 were smaller in the thoracoscopic group(P＜0.05);survival rate of 28 d in the thoracoscopic group was 2.63%,with 5.00%in the open chest surgery group,and the difference was not statistically significant(P＞0.05).Conclusion Compared with conventional thoracotomy, thoracoscopic resection has the characteristics of obvious curative effect,less trauma and quick recovery.Ⅰt is worth popularizing.

Key words： Thoracoscope Early peripheral lung cancer Radical resection Ⅰnflammation factors T lymphocyte subgroup level Ⅰmpact

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	Articles by authors
	ZENG Xin-min
	WANG Hui
	ZHANG Zhi-long
	HU Huo-li
	XU Xing-hua
	CHEN Hua

Cite this article:

ZENG Xin-min,WANG Hui,ZHANG Zhi-long, et al. The influence of radical surgery thoracoscope on TNF alpha,IL-6,IL-10 and level of T lymphocyte subsets of patients with early peripheral lung cancer[J]. 中国当代医药, 2016, 23(30): 65-68.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I30/65

[1]	张志强，申佃京，杜玉波.胸腔镜下肺癌根治术患者临床效果及免疫、炎性反应状态观察[J].海南医学，2012，23
（21）	：8-10.
[2]	吴伟铭，陈海泉，周建华，等.Muscle-Sparing开胸术与后外侧开胸术对肺癌患者免疫功能影响[J].中国癌症杂志，2009，19（3）：191-195.
[3]	黄庆飞，赵文，陈尚威，等.胸腔镜肺叶切除术84例的临床疗效分析[J].世界最新医学信息文摘，2014，14（4）：79.
[4]	孙燕，石远凯.临床肿瘤内科手册[M].5版.北京：人民卫生出版社，2007：476-491.
[5]	姜镕，马春华，朱子龙，等.脑脊液循环肿瘤细胞检测在非小细胞肺癌脑膜转移诊断中的应用[J].中国现代疾病杂志，2014，14（8）：704-707.
[6]	于占武，刘永煜，杨成良，等.胸腔镜肺癌根治术患者围术期机体免疫与应激状态变化[J].海南医学院学报，2014，20（4）：501-506.
[7]	Bobocea AC，Trandafir B，Bolca C，et al.Minimally invasive surgery in cancer.Ⅰmmunological response[J].Chirurgia，2012，107（2）：154-157.
[8]	吴建兵，洪瑞，方伟群.胸腔镜肺叶切除术对非小细胞肺癌患者术后免疫功能的影响[J].中国医学创新，2013，10（17）：11-13.
[9]	刘懿，赵洪林，刘京豪，等.胸腔镜早期周围型肺癌根治术对患者术后炎性反应状态的影响[J].中国肺癌杂志，2014，17（10）：730-733.
[10]	李明军.胸腔镜下肺叶切除治疗早期周围型肺癌的临床疗效及机体炎性反应观察[J].中国煤炭工业医学杂志，2013，16（10）：1620-1622.
[11]	阚奇伟，刘泗军，石勇，等.电视胸腔镜手术治疗胸部疾病疗效分析[J].局解手术学杂志，2013，22（6）：640-642.
[12]	张自正，刘汉云，李剑明，等.胸腔镜手术与传统开胸肺癌根治术后炎症因子及VEGF水平变化的比较[J].肿瘤基础与临床，2013，26（4）：331-334.
[13]	Ha D，Choi H，Zell K，et al.Association of impaired heart rate recovery with cardiopulmonary complications after lung cancer resection surgery[J].J Thorac Cardiovasc Surg，2015，149（4）：1168-1673.
[14]	饶新辉，刘汉云，梁锦崧，等.胸腔镜用于肺癌微创手术的可行性及对肺功能的影响[J].海南医学院学报，2015，21（9）：1232-1234.
[15]	仲崇浩，张思泉，史宏灿，等.胸腔镜肺癌根治术临床诊治分析[J].中华实验外科杂志，2015，32（12）：3112.