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| Curative effect of recombinant human interferon α-2a suppository combined with Baofukang suppository in the treatment of chronic cervicitis complicated with human papilloma virus infection |
| QIU Jin-zhu1 LIU Hong-yu2 |
1.Department of Pharmacy,Jiaoling People′s Hospital in Guangdong Province,Jiaoling 514100,China;
2.Department of Gynecology and Obstetrics,Jiaoling People′s Hospital in Guangdong Province,Jiaoling 514100,China |
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Abstract Objective To explore the effect of recombinant human interferon α-2a suppository combined with Baofukang suppository treating chronic cervicitis complicated with human papilloma virus（HPV）infection. Methods From March 2012 to December 2014,80 patients definitely diagnosed as chronic cervicitis complicated with HPV infection treated by our hospital were selected as research group.They were evenly divided into intervention group and control group in random.In control group,Baofukang suppository was used,while in intervention group,on the basis of control group,recombinant human interferon α-2a suppository was added.The duration time of abnormal secretion,wound healing time,HPV negative conversion ratio,clinical curative efficacy,and incidence rate of adverse reaction in patients between two groups was compared respectively. Results In intervention group,duration time of abnormal secretion and wound healing time was obviously shorter than that of control group（P＜0.05）.HPV negative conversion ratio after 4 and 8 months therapy was 52.5％and 80.0％in intervention group,and it was obviously higher than that of control group（30.0％and 57.5％）（P＜0.05）.The total effective rate in intervention group was 92.5％,and it was obviously higher than that of control group（80.0％）（P＜0.05）.There was no significant difference of occurrence rate of adverse reaction between two groups（P＞0.05）. Conclusion recombinant human interferon α-2a suppository combined with Baofukang suppository in the treatment of chronic cervicitis complicated with HPV infection has a remarkable effect,and it is worthy of clinical promotion and application.
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| [1] |
赵孟军，王世杰，魏文红.微波联合保妇康栓治疗慢性宫颈炎伴高危型HPV感染疗效分析[J].中国妇幼保健，2013，28（34）：5730-5731.
|
| [2] |
仝进毅，程琪辉，孙丽萍. T细胞亚群及Ki67在宫颈人乳头状瘤病毒感染进程中的变化及意义[J].中华医院感染学杂志，2012，22（6）：1126-1128.
|
| [3] |
李晶，刘志英，王博，等.女性生殖道人乳头状瘤病毒感染亚型分布分析[J].中华医院感染学杂志，2012，22（17）：3777-3779.
|
| [4] |
王艳霞，宋晓霞，刘玉玲.药物治疗340例宫颈乳头瘤病毒感染的临床观察[J].重庆医学，2012，41（27）：2860-2861.
|
| [5] |
薛杰韬，舒欣，樊娟，等.保妇康栓配合微波治疗宫颈持续HPV感染性疾病的临床疗效观察[J].中国妇幼保健，2013，28（22）：3682-3684.
|
| [6] |
吕倩灵，张玲，林伟平.高危型人乳头状瘤病毒及病毒载量对宫颈癌癌前病变的相关性分析[J].中华医院感染学杂志，2014，24（4）：804-805，856.
|
| [7] |
邓晓娥，王蔚蓝，司建英，等.高危型人乳头状瘤病毒导致宫颈癌的临床病理研究[J].中华医院感染学杂志，2014，24（5）：1057-1058，1069.
|
| [8] |
Xu X，Yang J，Lin N，et al.Semi-quantitative detection of HPV L1 capsid protein in exfoliative cytological examination facilitates the differential diagnosis of cervical lesions[J]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi，2014，30（11）：1194-1197.
|
| [9] |
周锦来，沈彩糯，陈洁洁.人乳头状瘤病毒宫颈糜烂感染保妇康栓治疗的疗效观察[J].中华医院感染学杂志，2014，24（8）：2037-2038，2041.
|
| [10] |
王双双，杨红耀，梁殿迅.微波联合复方沙棘籽油栓治疗宫颈炎患者人乳头状瘤病毒感染的研究[J].中华医院感染学杂志，2014，24（16）：4100-4102.
|
| [11] |
Lube G，Aikawa NE，Tacla M，et al.Condyloma acuminatum by human papilloma virus infection in childhoodsystemic lupus erythematosus patients[J].Acta Reumatol Port，2014，39（2）：182-187.
|
| [12] |
晋阳秋，魏鑫，彭丽娜.人乳头状瘤病毒及单纯疱疹病毒Ⅱ型感染与宫颈疾病的相关性研究[J].中华医院感染学杂志，2014，24（16）：3904-3906.
|
| [13] |
蒋欣，张亚军，江月，等.IMP3和HPV联合检测在宫颈上皮内瘤变筛查中的应用[J].诊断病理学杂志，2015，22（9）：554-557.
|
| [14] |
赵群，陈志恒，朱小玲，等.湖南省24817例体检妇女筛查宫颈病变结果分析[J].基础医学与临床，2015，35（4）：435-438.
|
| [15] |
吴彩娟，余玉香，罗健.宫颈疾病与生殖道高危型人乳头状瘤病毒感染的相关性分析[J].中华医院感染学杂志，2013，23（8）：1843-1845.
|
| [16] |
Ding YX，Cheng Y，Sun QM，et al.Mechanical characterization of cervical squamous carcinoma cells by atomic force microscopy at nanoscale[J].Med Oncol，2015，32（3）：71.
|
| [17] |
王国权，吴晓兰，邹富梅.氧驱动雾化吸入重组人干扰素-α2a注射液治疗婴幼儿毛细支气管炎的疗效观察[J].中国现代医生，2015，53（10）：33-35，39.
|
|
|
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