强直性脊柱炎患者心脏受累危险因素研究

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Abstract Objective To exp1ore the preva1ence rate of cardiac invo1vement in the patients with anky1osing spondy1itis （AS），to observe the performance of cardiac invo1vement，and to ana1yze the corre1ations of AS cardiac invo1vement with age，gender，course of disease，1aboratory indices，1ong_term hormone treatment，and 1ong_term immunosuppressor treatment.Methods 131 hospita1ized patients with AS（group A）who were diagnosedin our hospita1 from January 2014 to November 2015 were retrospective1y ana1yzed.Among them，61 patients　（46.56%）comp1icated with cardiac invo1vement i.e. ECG and　（or）abnorma1 UCG were se1ected in the research group　（group A1），and the patients without cardiac invo1vement（53.43%）were se1ected in the contro1 group（group A2）.217 peop1e who were given ECG and UCG examinations in the physica1 examination center in our hospita1 were se1ected as the hea1thy group　（group B）at the same time.Re1evant 1aboratory indices were compared between group A1 and group A2.Logistic regression ana1ysis was carried out for susceptib1e risk factors which were statistica11y significant in the univariate intra_group comparison，and risk factors were determined.Results The preva1ence rate of cardiac invo1vement in group A was 46.56%　（61/131），and that in group B was 22.58%　（49/217），the differences between two groups were statistica11y significant（P＜0.05）.There were no statistica11y significant differences between group A1 and group A2 in terms of age，course of disease，smoking，a1coho1 drinking，HLA_B27 and 1ong_term immunosuppressor treatment（P＞0.05）.There were statistica11y significant differences of ESR，Hb，gender and 1ong_term hormone treatment（P＜0.05）.According to the 1ogistic regression ana1ysis，1ong_term hormone therapy and high ESR va1ue were risk factors for cardiac invo1vement in the patients with AS.Conclusion Long_term hormone therapy and high ESR va1ue are risk factors for cardiac invo1vement in the patients with AS.

Key words： Anky1osing spondy1itis Cardiac invo1vement Retrospective ana1ysis

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	XUE Xiao-yan
	LI Jun-xia
	LI Xiao-feng

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XUE Xiao-yan,LI Jun-xia,LI Xiao-feng. Study of the risk factors for cardiac involvement in the patients with ankylosing spondylitis[J]. 中国当代医药, 2016, 23(12): 22-25.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I12/22

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