Objective To explore the method and effect of improving the monitoring stability of infant blood oxyhemoglobin saturation(SpO2).Methods A total of 60 children who needed continuous ECG monitoring in the pediatric intensive care unit(PICU)of Yichun Maternal and Child Health Hospital from February to June 2020 were selected as the subjects.According to random number table method,they were divided into the control group and the observation group,with 30 cases in each group.The control group was fixed by conventional blood oxygen probe,and the observation group was fixed by external blood oxygen probe with black cloth.The blood SpO2 was continuously monitored for more than 8 hours in both groups.During the monitoring process,registration was performed every 30 minutes.SpO2 level,frequency of probe dropping,frequency of nurse rework,standard rate and family satisfaction were compared between the two groups.Results There were no statistically significant differences in SpO2 levels between the two groups at the time of immediate monitoring,4 and 8 h monitoring(P＞0.05).The frequency of probe dropping and nurse rework in the observation group were less than those in the control group,and the differences were statistically significant(P＜0.05).The standard rate of SpO2 monitoring in the observation group and the satisfaction of the children′s families on the monitoring method,monitoring effect and service attitude were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The method of black cloth external fixed blood oxygen probe has a high stability in the monitoring of blood SpO2 of infants,which can reduce the frequency of probe dropping and nurse rework,and improve nursing satisfaction,it is worthy of popularization and application.